Edward Giniger
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Explore the profile of Edward Giniger including associated specialties, affiliations and a list of published articles.
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53
Citations
1939
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Recent Articles
1.
Wodrich A, Harris B, Giniger E
Biol Open
. 2024 Sep;
13(10).
PMID: 39292114
Reactive oxygen species (ROS) are associated with aging and neurodegeneration, but the significance of this association remains obscure. Here, using a Drosophila Cdk5 model of age-related neurodegeneration, we probe this...
2.
Wodrich A, Harris B, Giniger E
Biol Open
. 2024 Jun;
13(7).
PMID: 38912559
Changes in mitochondrial distribution are a feature of numerous age-related neurodegenerative diseases. In Drosophila, reducing the activity of Cdk5 causes a neurodegenerative phenotype and is known to affect several mitochondrial...
3.
Wodrich A, Harris B, Giniger E
bioRxiv
. 2024 Apr;
PMID: 38585927
Reactive oxygen species (ROS) are associated with aging and neurodegeneration, but the significance of this association remains obscure. Here, using a model of age-related neurodegeneration, we probe this relationship in...
4.
Wodrich A, Harris B, Giniger E
bioRxiv
. 2024 Feb;
PMID: 38405730
Changes in mitochondrial distribution are a feature of numerous age-related neurodegenerative diseases. In , reducing the activity of Cdk5 causes a neurodegenerative phenotype and is known to affect several mitochondrial...
5.
Wodrich A, Scott A, Giniger E
Mech Ageing Dev
. 2023 Jun;
213:111839.
PMID: 37354919
What is the nature of aging, and how best can we study it? Here, using a series of questions that highlight differing perspectives about the nature of aging, we ask...
6.
Forghani R, Chandrasekaran A, Papoian G, Giniger E
Open Biol
. 2023 Jun;
13(6):220359.
PMID: 37282493
The mechanism of axon growth and guidance is a core, unsolved problem in neuroscience and cell biology. For nearly three decades, our view of this process has largely been based...
7.
Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone in
Fang H, Forghani R, Clarke A, McQueen P, Chandrasekaran A, ONeill K, et al.
Mol Biol Cell
. 2023 May;
34(8):ar83.
PMID: 37223966
Ena/VASP proteins are processive actin polymerases that are required throughout animal phylogeny for many morphogenetic processes, including axon growth and guidance. Here we use in vivo live imaging of morphology...
8.
Koca Y, Vuong L, Singh J, Giniger E, Mlodzik M
Cell Rep
. 2022 Dec;
41(10):111788.
PMID: 36476875
A collective cell motility event that occurs during Drosophila eye development, ommatidial rotation (OR), serves as a paradigm for signaling-pathway-regulated directed movement of cell clusters. OR is instructed by the...
9.
Li H, Sung H, Huang Y, Cheng Y, Yeh H, Pi H, et al.
Cell Rep
. 2022 Sep;
40(12):111372.
PMID: 36130510
Golgi outposts (GOPs) in dendrites are known for their role in promoting branch extension, but whether GOPs have other functions is unclear. We found that terminal branches of Drosophila class...
10.
Chandrasekaran A, Giniger E, Papoian G
Biophys J
. 2022 Aug;
121(17):3200-3212.
PMID: 35927959
Actin networks rely on nucleation mechanisms to generate new filaments because spontaneous nucleation is kinetically disfavored. Branching nucleation of actin filaments by actin-related protein (Arp2/3), in particular, is critical for...