Edward Gabrielson
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Explore the profile of Edward Gabrielson including associated specialties, affiliations and a list of published articles.
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131
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8866
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Recent Articles
11.
Pharmacodynamic measures within tumors expose differential activity of PD(L)-1 antibody therapeutics
Kumar D, Mishra A, Lisok A, Kureshi R, Shelake S, Plyku D, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(37).
PMID: 34508005
Macromolecules such as monoclonal antibodies (mAbs) are likely to experience poor tumor penetration because of their large size, and thus low drug exposure of target cells within a tumor could...
12.
Yan Y, Narayan A, Cho S, Cheng Z, Liu J, Zhu H, et al.
Oncogene
. 2021 Aug;
40(38):5752-5763.
PMID: 34341513
Expression of β-crystallin B2 (CRYβB2) is elevated in African American (AA) breast tumors. The underlying mechanisms of CRYβB2-induced malignancy and the association of CRYβB2 protein expression with survival have not...
13.
Zhou Y, Lih T, Pan J, Hoti N, Dong M, Cao L, et al.
J Hematol Oncol
. 2020 Dec;
13(1):170.
PMID: 33287876
Background: Proteomic characterization of cancers is essential for a comprehensive understanding of key molecular aberrations. However, proteomic profiling of a large cohort of cancer tissues is often limited by the...
14.
Singh A, Daemen A, Nickles D, Jeon S, Foreman O, Sudini K, et al.
Clin Cancer Res
. 2020 Oct;
27(3):877-888.
PMID: 33077574
Purpose: Stabilization of the transcription factor NRF2 through genomic alterations in and occurs in a quarter of patients with lung adenocarcinoma and a third of patients with lung squamous cell...
15.
Anagnostou V, Niknafs N, Marrone K, Bruhm D, White J, Naidoo J, et al.
Nat Cancer
. 2020 Sep;
1(1):99-111.
PMID: 32984843
Despite progress in immunotherapy, identifying patients that respond has remained a challenge. Through analysis of whole-exome and targeted sequence data from 5,449 tumors, we found a significant correlation between tumor...
16.
Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon honokiol treatment
Muniraj N, Siddharth S, Shriver M, Nagalingam A, Parida S, Woo J, et al.
Cell Death Discov
. 2020 Sep;
6:81.
PMID: 32963809
Cancer cells hijack autophagy pathway to evade anti-cancer therapeutics. Many molecular signaling pathways associated with drug-resistance converge on autophagy induction. Honokiol (HNK), a natural phenolic compound purified from , has...
17.
Shibata M, Ooki A, Inokawa Y, Sadhukhan P, Ugurlu M, Izumchenko E, et al.
Mol Cancer Ther
. 2020 Aug;
19(10):2175-2185.
PMID: 32847981
Cancer stem cells (CSC) are highly resistant to conventional chemotherapeutic drugs. YAP1 and STAT3 are the two transcription factors that facilitate the therapeutic resistance and expansion of CSCs. The objective...
18.
Zhou Y, Yang W, Ao M, Hoti N, Gabrielson E, Chan D, et al.
Front Oncol
. 2020 Jul;
10:1072.
PMID: 32719746
Bronchoalveolar lavage (BAL) is a specific type of air-way fluid. It is a commonly used clinical specimen for the diagnosis of benign diseases and cancers of the lung. Although previous...
19.
Fackler M, Cho S, Cope L, Gabrielson E, Visvanathan K, Wilsbach K, et al.
NPJ Breast Cancer
. 2020 Feb;
6:3.
PMID: 32025567
We lack tools to risk-stratify triple-negative breast cancer (TNBC). Our goal was to develop molecular tools to predict disease recurrence. Methylation array analysis was performed on 110 samples treated by...
20.
Zhang J, Ji Z, Caushi J, El Asmar M, Anagnostou V, Cottrell T, et al.
Clin Cancer Res
. 2019 Nov;
26(6):1327-1337.
PMID: 31754049
Purpose: Neoadjuvant PD-1 blockade is a promising treatment for resectable non-small cell lung cancer (NSCLC), yet immunologic mechanisms contributing to tumor regression and biomarkers of response are unknown. Using paired...