Edward D Karoly
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Explore the profile of Edward D Karoly including associated specialties, affiliations and a list of published articles.
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57
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3470
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Recent Articles
1.
Li V, Xiao S, Schlosser P, Scherer N, Wiggenhorn A, Spaas J, et al.
Nat Commun
. 2024 Aug;
15(1):6895.
PMID: 39134528
N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses food intake and body weight. Little is known about the mechanisms that mediate Lac-Phe transport across cell membranes. Here we identify SLC17A1...
2.
Li V, Xiao S, Schlosser P, Scherer N, Wiggenhorn A, Spaas J, et al.
bioRxiv
. 2024 Apr;
PMID: 38659895
N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses food intake and body weight. Little is known about the mechanisms that mediate Lac-Phe transport across cell membranes. Here we identify SLC17A1...
3.
Schlosser P, Scherer N, Grundner-Culemann F, Monteiro-Martins S, Haug S, Steinbrenner I, et al.
Nat Genet
. 2023 Jun;
55(6):995-1008.
PMID: 37277652
The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of paired plasma and urine metabolomes may identify underlying...
4.
Hysi P, Mangino M, Christofidou P, Falchi M, Karoly E, Nihr Bioresource Investigators , et al.
Metabolites
. 2022 Jan;
12(1).
PMID: 35050183
Metabolites are small products of metabolism that provide a snapshot of the wellbeing of an organism and the mechanisms that control key physiological processes involved in health and disease. Here...
5.
Kotsis F, Schultheiss U, Wuttke M, Schlosser P, Mielke J, Becker M, et al.
J Am Soc Nephrol
. 2021 Jun;
32(9):2315-2329.
PMID: 34140400
Background: Polypharmacy is common among patients with CKD, but little is known about the urinary excretion of many drugs and their metabolites among patients with CKD. Methods: To evaluate self-reported...
6.
Jamshidi N, Xu X, von Lohneysen K, Soldau K, Mohney R, Karoly E, et al.
iScience
. 2020 Oct;
23(10):101630.
PMID: 33103072
Understanding the mechanisms for cellular aging is a fundamental question in biology. Normal red blood cells (RBCs) survive for approximately 100 days, and their survival is likely limited by functional...
7.
J Snow S, Broniowska K, Karoly E, Henriquez A, Phillips P, Ledbetter A, et al.
Sci Rep
. 2020 Oct;
10(1):16353.
PMID: 33004997
The influence of maternal high-fat diet (HFD) on metabolic response to ozone was examined in Long-Evans rat offspring. F0 females were fed control diet (CD; 10%kcal from fat) or HFD...
8.
Labbe D, Zadra G, Yang M, Reyes J, Lin C, Cacciatore S, et al.
Nat Commun
. 2019 Sep;
10(1):4358.
PMID: 31554818
Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association...
9.
Cho Y, Osgood R, Bell L, Karoly E, Shore S
PLoS One
. 2019 Aug;
14(8):e0221633.
PMID: 31454377
Ozone is an asthma trigger. In mice, the gut microbiome contributes to ozone-induced airway hyperresponsiveness, a defining feature of asthma, but the mechanistic basis for the role of the gut...
10.
Cheng W, Duncan K, Ghio A, Ward-Caviness C, Karoly E, Diaz-Sanchez D, et al.
Toxicol Sci
. 2018 Feb;
163(2):430-439.
PMID: 29471466
Controlled human exposure to the oxidant air pollutant ozone causes decrements in lung function and increased inflammation as evidenced by neutrophil influx into the lung and increased levels of proinflammatory...