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Edward D Johnstone

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Citations 574
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Recent Articles
1.
Popp C, Carson J, Drysdale A, Arora H, Johnstone E, Myers J, et al.
Sci Rep . 2024 Oct; 14(1):23144. PMID: 39367038
Computational models can be at the basis of new powerful technologies for studying and classifying disorders like pre-eclampsia, where it is difficult to distinguish pre-eclamptic patients from non-pre-eclamptic based on...
2.
Khalil A, Prasad S, Woolfall K, Mitchell T, Kirkham J, Yaghi O, et al.
BMJ Open . 2024 Aug; 14(8):e080021. PMID: 39153765
Introduction: Selective fetal growth restriction (sFGR) in monochorionic twin pregnancy, defined as an estimated fetal weight (EFW) of one twin <10th centile and EFW discordance ≥25%, is associated with stillbirth...
3.
Sharp A, Cornforth C, Jackson R, Harrold J, Turner M, Kenny L, et al.
BJOG . 2024 Jun; 131(12):1673-1683. PMID: 38923115
Objective: Severe early-onset fetal growth restriction (FGR) causes stillbirth, neonatal death and neurodevelopmental impairment. Poor maternal spiral artery remodelling maintains vasoactive responsiveness but is susceptible to treatment with sildenafil, a...
4.
Cristinacce P, Patel M, Oh A, Naish J, Johnstone E, Ingram E
PLoS One . 2024 May; 19(5):e0302623. PMID: 38776318
Oxygen-Enhanced Magnetic Resonance Imaging (OE-MRI) of the human placenta is potentially a sensitive marker of in vivo oxygenation. This methodological study shows that full coverage of the placenta is possible...
5.
Hammer L, Heazell A, Povey A, Myers J, Thompson J, Johnstone E
BJOG . 2023 Oct; 131(5):598-609. PMID: 37880925
Objective: We examined whether the risk of stillbirth was related to ambient air pollution in a UK population. Design: Prospective case-control study. Setting: Forty-one maternity units in the UK. Population:...
6.
Ormesher L, Worton S, Best A, Dodd S, Dempsey A, Cottrell E, et al.
Reprod Sci . 2023 Oct; 31(2):560-568. PMID: 37789125
Oral supplementation with L-citrulline, which is sequentially converted to L-arginine then nitric oxide, improves vascular biomarkers and reduces blood pressure in non-pregnant, hypertensive human cohorts and pregnant mice with a...
7.
Tropea T, Mavichak W, Evangelinos A, Brennan-Richardson C, Cottrell E, Myers J, et al.
J Hypertens . 2023 Sep; 41(11):1675-1687. PMID: 37694528
Maternal cardiovascular diseases, including hypertension and cardiac conditions, are associated with poor fetal outcomes. A range of adrenergic antihypertensive and cardioprotective medications are often prescribed to pregnant women to reduce...
8.
Ormesher L, Vause S, Higson S, Roberts A, Clarke B, Curtis S, et al.
Sci Rep . 2023 Jan; 13(1):153. PMID: 36599871
Pre-eclampsia is associated with postnatal cardiac dysfunction; however, the nature of this relationship remains uncertain. This multicentre retrospective cohort study aimed to determine the prevalence of pre-eclampsia in women with...
9.
Johnstone E, Westwood M, Dilworth M, Wray J, Kendall A, Nicolaou A, et al.
J Lipid Res . 2022 Nov; 64(1):100312. PMID: 36370808
Sphingolipids like sphingosine-1-phosphate (S1P) have been implicated in the pathophysiology of pre-eclampsia. We hypothesized that plasma S1P would be increased in women at high risk of developing pre-eclampsia who subsequently...
10.
Ormesher L, Higson S, Luckie M, Roberts S, Glossop H, Trafford A, et al.
Pregnancy Hypertens . 2022 Aug; 30:68-81. PMID: 36029727
Objective: To explore the nature of postnatal cardiovascular morbidity following pregnancies complicated by preterm pre-eclampsia and investigate associations between pregnancy characteristics and maternal postnatal cardiovascular function. Study Design: This was...