Edward C Frackelton
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Explore the profile of Edward C Frackelton including associated specialties, affiliations and a list of published articles.
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37
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3792
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Recent Articles
1.
Huang Y, Dinh A, Heron S, Gasiewski A, Kneib C, Mehler H, et al.
Am J Transplant
. 2019 Jan;
19(7):1955-1963.
PMID: 30623581
HLA typing in solid organ transplantation (SOT) is necessary for determining HLA-matching status between donor-recipient pairs and assessing patients' anti-HLA antibody profiles. Histocompatibility has traditionally been evaluated based on serologically...
2.
Wang K, Zhang H, Mentch F, Bradfield J, Glessner J, Qiu H, et al.
J Pediatr Genet
. 2016 Sep;
1(2):85-98.
PMID: 27625808
Previous large-scale genome-wide association studies in adult populations have implicated ∽100 loci in determining high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, or triglyceride levels. However, whether these loci also contribute...
3.
Grant S, Petri M, Bradfield J, Kim C, Santa E, Annaiah K, et al.
Appl Clin Genet
. 2013 Jun;
2:1-5.
PMID: 23776345
Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs10516487, within the B-cell gene BANK1 and systemic lupus erythematosus (SLE) as a consequence of a genome wide association...
4.
Deliard S, Panossian S, Mentch F, Kim C, Hou C, Frackelton E, et al.
Obesity (Silver Spring)
. 2013 Mar;
21(1):159-63.
PMID: 23505181
Objective: Common variation at the loci harboring fat mass and obesity (FTO), melanocortin receptor 4 (MC4R), and transmembrane protein 18 (TMEM18) is consistently reported as being statistically most strongly associated...
5.
Couthouis J, Hart M, Erion R, King O, Diaz Z, Nakaya T, et al.
Hum Mol Genet
. 2012 Mar;
21(13):2899-911.
PMID: 22454397
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. Mutations in related RNA-binding proteins TDP-43, FUS/TLS and TAF15 have been connected to ALS. These three proteins share...
6.
Elia J, Glessner J, Wang K, Takahashi N, Shtir C, Hadley D, et al.
Nat Genet
. 2011 Dec;
44(1):78-84.
PMID: 22138692
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) study on 1,013 cases with ADHD and 4,105...
7.
Bradfield J, Qu H, Wang K, Zhang H, Sleiman P, Kim C, et al.
PLoS Genet
. 2011 Oct;
7(9):e1002293.
PMID: 21980299
Diabetes impacts approximately 200 million people worldwide, of whom approximately 10% are affected by type 1 diabetes (T1D). The application of genome-wide association studies (GWAS) has robustly revealed dozens of...
8.
Zhao J, Bradfield J, Zhang H, Sleiman P, Kim C, Glessner J, et al.
Obesity (Silver Spring)
. 2011 Jul;
19(12):2436-9.
PMID: 21779088
Obesity is a serious health concern for children and adolescents, particularly in Western societies, where its incidence is now considered to have reached epidemic proportions. A number of genetic determinants...
9.
Zhao J, Bradfield J, Li M, Zhang H, Mentch F, Wang K, et al.
Obesity (Silver Spring)
. 2011 Jan;
19(6):1311-4.
PMID: 21212767
Recent genome wide association studies (GWAS) have revealed a number of genetic variants robustly associated with bone mineral density (BMD) and/or osteoporosis. Evidence from epidemiological and clinical studies has shown...
10.
Lanktree M, Guo Y, Murtaza M, Glessner J, Bailey S, Onland-Moret N, et al.
Am J Hum Genet
. 2011 Jan;
88(1):6-18.
PMID: 21194676
Height is a classic complex trait with common variants in a growing list of genes known to contribute to the phenotype. Using a genecentric genotyping array targeted toward cardiovascular-related loci,...