Edward Arnold
Overview
Explore the profile of Edward Arnold including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
271
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0
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Recent Articles
1.
Smith M, Ruby S, Horouzhenko S, Buckingham B, Richardson J, Puleri I, et al.
Drug Des Discov
. 2004 Nov;
18(4):151-63.
PMID: 15553926
The energies and physical descriptors for the binding of 21 novel 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazole (BPBI) analogs to HIV-1 reverse transcriptase (RT) variants Y181C, L100I, V106A, and K103N have been determined using Monte...
2.
Boyer P, Imamichi T, Sarafianos S, Arnold E, Hughes S
J Virol
. 2004 Aug;
78(18):9987-97.
PMID: 15331732
Long-term use of combination therapy against human immunodeficiency virus type (HIV-1) provides strong selective pressure on the virus, and HIV-1 variants that are resistant to multiple inhibitors have been isolated....
3.
Mulky A, Sarafianos S, Arnold E, Wu X, Kappes J
J Virol
. 2004 Jun;
78(13):7089-96.
PMID: 15194785
The human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is a heterodimer comprised of two structurally distinct subunits (p51 and p66). Since p51 and p66 are derived from the...
4.
Peletskaya E, Kogon A, Tuske S, Arnold E, Hughes S
J Virol
. 2004 Mar;
78(7):3387-97.
PMID: 15016861
Site-directed photoaffinity cross-linking experiments were performed by using human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutants with unique cysteine residues at several positions (i.e., positions 65, 67, 70,...
5.
McWilliams M, Julias J, Sarafianos S, Alvord W, Arnold E, Hughes S
J Virol
. 2003 Sep;
77(20):11150-7.
PMID: 14512562
The RNase H activity of retroviral reverse transcriptases (RTs) degrades viral genomic RNA after it has been copied into DNA, removes the tRNA used to initiate negative-strand DNA synthesis, and...
6.
Julias J, McWilliams M, Sarafianos S, Alvord W, Arnold E, Hughes S
J Virol
. 2003 Jul;
77(15):8548-54.
PMID: 12857924
The crystal structure of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase in a complex with an RNA-DNA template-primer identified amino acids in the connection domain that make specific contacts...
7.
Shen L, Shen J, Luo X, Cheng F, Xu Y, Chen K, et al.
Biophys J
. 2003 May;
84(6):3547-63.
PMID: 12770866
HIV-1 reverse transcriptase (RT) is the primary target for anti-AIDS chemotherapy. Nonnucleoside RT inhibitors (NNRTIs) are very potent and most promising anti-AIDS drugs that specifically inhibit HIV-1 RT. The binding...
8.
Smith M, Hose B, Hawkins A, Lipchock J, Farnsworth D, Rizzo R, et al.
J Med Chem
. 2003 May;
46(10):1940-7.
PMID: 12723956
The energies and physical descriptors for the binding of 20 novel 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)benzimidazole analogues (BPBIs) to HIV-1 reverse transcriptase (RT) have been determined using Monte Carlo (MC) simulations. The crystallographic structure...
9.
Skillman A, Maurer K, Roe D, Stauber M, Eargle D, Ewing T, et al.
Bioorg Chem
. 2003 Mar;
30(6):443-58.
PMID: 12642128
The human immunodeficiency virus (HIV) epidemic is an important medical problem. Although combination drug regimens have produced dramatic decreases in viral load, current therapies do not provide a cure for...
10.
Boyer P, Sarafianos S, Arnold E, Hughes S
J Virol
. 2002 Aug;
76(18):9143-51.
PMID: 12186898
Although anti-human immunodeficiency virus type 1 (HIV-1) therapy has prolonged the lives of patients, drug resistance is a significant problem. Of particular concern are mutations that cause cross-resistance to a...