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» Authors » Edvard Wigren

Edvard Wigren

Explore the profile of Edvard Wigren including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 195
Followers 0
Related Specialties
Microbiology
Rheumatology
Biochemistry
Top 10 Co-Authors
Susanne Graslund
Ingrid E Lundberg
Catia Fernandes-Cerqueira
Helena Persson
Charlotta Preger
Antonella Notarnicola
Per-Johan Jakobsson
Ute Romling
Ylva Lindqvist
Angeles S Galindo-Feria
Published In
Rheumatology (Oxford)
J Biol Chem
Mol Microbiol
Arthritis Res Ther
J Mol Biol
Affiliations
Soon will be listed here.
Recent Articles
1.
Correction: Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome
Notarnicola A, Preger C, Lundstrom S, Renard N, Wigren E, Van Gompel E, et al.
Arthritis Res Ther . 2024 Dec; 26(1):206. PMID: 39623418
No abstract available.
2.
Anti-FHL1 autoantibodies in adult patients with myositis: a longitudinal follow-up analysis
Galindo-Feria A, Lodin K, Horuluoglu B, Sarrafzadeh-Zargar S, Wigren E, Graslund S, et al.
Rheumatology (Oxford) . 2024 Jun; 64(3):1482-1492. PMID: 38833674
Objectives: To determine prevalence and clinical associations of anti-Four-and-a-half-LIM-domain 1 (FHL1) autoantibodies in patients with idiopathic inflammatory myopathies (IIM) and to evaluate autoantibody levels over time. Methods: Sera at the...
3.
Autoantibodies against the melanoma differentiation-associated protein 5 in patients with dermatomyositis target the helicase domains
Van Gompel E, Demirdal D, Fernandes-Cerqueira C, Horuluoglu B, Galindo-Feria A, Wigren E, et al.
Rheumatology (Oxford) . 2023 Aug; 63(5):1466-1473. PMID: 37572295
Objectives: Clinical observations in patients with dermatomyositis (DM) and autoantibodies against the melanoma differentiation-associated protein 5 (MDA5) suggest that the autoantibodies contribute to the pathogenesis of MDA5(+) DM. To gain...
4.
Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies
Preger C, Notarnicola A, Hellstrom C, Wigren E, Fernandes-Cerqueira C, Kvarnstrom M, et al.
J Autoimmun . 2022 Dec; 134:102951. PMID: 36470210
Objectives: Autoantibodies are thought to play a key role in the pathogenesis of idiopathic inflammatory myopathies (IIM). However, up to 40% of IIM patients, even those with clinical manifestations of...
5.
Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome
Notarnicola A, Preger C, Lundstrom S, Renard N, Wigren E, Van Gompel E, et al.
Arthritis Res Ther . 2022 Mar; 24(1):62. PMID: 35236390
Background: To address the reactivity and affinity against histidyl-transfer RNA synthetase (HisRS) autoantigen of anti-Jo1 autoantibodies from serum and bronchoalveolar lavage fluid (BALF) in patients with idiopathic inflammatory myopathies/anti-synthetase syndrome...
6.
Autoantibodies against four-and-a-half-LIM domain 1 (FHL1) in inflammatory myopathies: results from an Australian single-centre cohort
Galindo-Feria A, Horuluoglu B, Day J, Fernandes-Cerqueira C, Wigren E, Graslund S, et al.
Rheumatology (Oxford) . 2022 Jan; 61(10):4145-4154. PMID: 35022656
Objectives: To determine the prevalence and associations of autoantibodies targeting a muscle-specific autoantigen, four-and-a-half-LIM-domain 1 (FHL1), in South Australian patients with histologically-confirmed idiopathic inflammatory myopathies (IIM) and in patients with...
7.
Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain
Szykowska A, Chen Y, Smith T, Preger C, Yang J, Qian D, et al.
Structure . 2021 Jul; 29(11):1241-1252.e5. PMID: 34233201
Mutations in TREM2, a receptor expressed by microglia in the brain, are associated with an increased risk of neurodegeneration, including Alzheimer's disease. Numerous studies support a role for TREM2 in...
8.
Generation and validation of recombinant antibodies to study human aminoacyl-tRNA synthetases
Preger C, Wigren E, Ossipova E, Marks C, Lengqvist J, Hofstrom C, et al.
J Biol Chem . 2020 Aug; 295(41):13981-13993. PMID: 32817337
Aminoacyl-tRNA synthetases (aaRSs) have long been viewed as mere housekeeping proteins and have therefore often been overlooked in drug discovery. However, recent findings have revealed that many aaRSs have noncanonical...
9.
Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients
Idborg H, Zandian A, Ossipova E, Wigren E, Preger C, Mobarrez F, et al.
Front Immunol . 2019 Jun; 10:1029. PMID: 31156624
Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease, which currently lacks specific diagnostic biomarkers. The diversity within the patients obstructs clinical trials but may also reflect differences in underlying...
10.
Patients with anti-Jo1 antibodies display a characteristic IgG Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies
Fernandes-Cerqueira C, Renard N, Notarnicola A, Wigren E, Graslund S, Zubarev R, et al.
Sci Rep . 2018 Dec; 8(1):17958. PMID: 30560888
IgG Fc-glycans affect IgG function and are altered in autoimmune diseases and autoantibodies. Anti-histidyl tRNA synthetase autoantibodies (anti-Jo1) are frequent in patients with idiopathic inflammatory myopathies (IIM) and anti-synthetase syndrome...