Eder J Lenardao
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Explore the profile of Eder J Lenardao including associated specialties, affiliations and a list of published articles.
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49
Citations
248
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Recent Articles
1.
Bartz R, Hellwig P, Rosa K, Silva M, Lenardao E, Jacob R, et al.
Org Biomol Chem
. 2025 Feb;
PMID: 39930985
Heterocyclic molecules containing organochalcogens are important scaffolds that have attracted scientific interest due to their remarkable pharmacological properties. As a consequence, in recent years several protocols have been developed for...
2.
Bartz R, Santos R, Hellwig P, Silva M, Lenardao E, Jacob R, et al.
Chem Asian J
. 2024 Sep;
19(24):e202400974.
PMID: 39297661
A practical strategy for obtaining novel 5-seleno-substituted spirocyclopenta[b]pyridines-2,5-dien-4-ones and benzo[h]quinolines via radical cyclization is reported. The synthetic protocol explores the reaction between arylethynylpyridines and diorganyl diselenides in acetonitrile as solvent...
3.
Anghinoni J, Ferreira S, Kazmierczak J, Perin G, Penteado F, Lenardao E
J Org Chem
. 2024 Aug;
89(16):11272-11280.
PMID: 39088563
Herein, we describe the use of benzeneseleninic acid derivatives (BSA) as a bench-stable and easy to handle selenium reagent to access 4-(selanyl)isoquinoline--oxides through the selenocyclization of -alkynyl benzaldehyde oximes. The...
4.
Hellwig P, Bartz R, Santos R, Guedes J, Silva M, Lenardao E, et al.
Chempluschem
. 2024 Mar;
89(6):e202300690.
PMID: 38426670
In this work, we describe the synthesis of new 4-organyl-5-(organylselanyl)thiazol-2-amine hybrids through a one-pot two-step protocol. The transition metal-free method involves the use of ultrasound as an alternative energy source...
5.
Anghinoni J, Birmann P, da Rocha M, Gomes C, Davies M, Bruning C, et al.
Molecules
. 2023 Nov;
28(21).
PMID: 37959771
Selenium is an essential trace element in living organisms, and is present in selenoenzymes with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). The search for small selenium-containing...
6.
Castro E, Alves A, de Bittencourt Maia D, Magalhaes L, Paim M, Penteado F, et al.
J Biochem Mol Toxicol
. 2023 Sep;
38(1):e23535.
PMID: 37711070
Redox imbalance leads to oxidative stress that causes irreversible cellular damage. The incorporation of the antioxidant element selenium (Se) in the structure of pyridinium salts has been used as a...
7.
Anghinoni J, Ferreira S, Piquini P, Iglesias B, Perin G, Penteado F, et al.
Chemistry
. 2023 Aug;
29(59):e202301934.
PMID: 37544915
Herein, we describe a new method for the synthesis of α-carbonyl selenocyanates by reacting triselenium dicyanide (TSD) and styrenes under blue light irradiation and O atmosphere. The reactions are triggered...
8.
Monzon L, Rocha N, Quadros G, Nunes P, Cargnelutti R, Jacob R, et al.
Molecules
. 2023 Jul;
28(13).
PMID: 37446698
A general methodology to access valuable 4-(phenylchalcogenyl)tetrazolo[1,5-]quinolines was developed by the reaction of 2-azidobenzaldehyde with phenylchalcogenylacetonitriles (sulfur and selenium) in the presence of potassium carbonate (20 mol%) as a catalyst....
9.
Bartz R, Silva K, Peglow T, Barcellos A, Jacob R, Lenardao E, et al.
Org Biomol Chem
. 2022 Nov;
20(45):8952-8961.
PMID: 36326093
We report a strategy for the direct synthesis of 3-organylselanylthiochromones and 3-organylselanylchromones the radical cyclization reaction between alkynyl aryl ketones containing an -thiopropyl/methoxy group and diorganyl diselenides promoted by Oxone®....
10.
Sarturi J, Dornelles L, Segatto N, Collares T, Seixas F, Piccoli B, et al.
Curr Med Chem
. 2022 Sep;
30(21):2449-2462.
PMID: 36065927
Background: This study presents the synthesis and multi-target behavior of the new 5'-hydroxy-3-(chalcogenyl-triazoyl)-thymidine and the biological evaluation of these compounds as antioxidant and anti-HIV agents. Objective: Antiretroviral therapy induces oxidative...