Eamonn Reading
Overview
Explore the profile of Eamonn Reading including associated specialties, affiliations and a list of published articles.
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26
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1300
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Recent Articles
1.
Russell Lewis B, Uddin M, Kuo K, Shah L, Harris N, Booth P, et al.
Structure
. 2025 Jan;
33(3):552-565.e4.
PMID: 39809273
Tripartite resistance nodulation and cell division multidrug efflux pumps span the periplasm and are major drivers of multidrug resistance among gram-negative bacteria. Cations, such as Mg, become concentrated within the...
2.
Russell Lewis B, Uddin M, Kuo K, Shah L, Harris N, Booth P, et al.
bioRxiv
. 2024 Jun;
PMID: 38915626
Tripartite resistance nodulation and cell division multidrug efflux pumps span the periplasm and are a major driver of multidrug resistance among Gram-negative bacteria. The periplasm provides a distinct environment between...
3.
Russell Lewis B, Uddin M, Moniruzzaman M, Kuo K, Higgins A, Shah L, et al.
Nat Commun
. 2023 Jul;
14(1):3900.
PMID: 37463890
Membrane efflux pumps play a major role in bacterial multidrug resistance. The tripartite multidrug efflux pump system from Escherichia coli, AcrAB-TolC, is a target for inhibition to lessen resistance development...
4.
Baggen J, Jacquemyn M, Persoons L, Vanstreels E, Pye V, Wrobel A, et al.
Cell
. 2023 Jul;
186(16):3427-3442.e22.
PMID: 37421949
SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal transmembrane protein, can...
5.
Calvaresi V, Wrobel A, Toporowska J, Hammerschmid D, Doores K, Bradshaw R, et al.
Nat Commun
. 2023 Mar;
14(1):1421.
PMID: 36918534
SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequent membrane fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 receptor, and an open...
6.
Hammerschmid D, Calvaresi V, Bailey C, Russell Lewis B, Politis A, Morris M, et al.
Anal Chem
. 2023 Jan;
95(5):3002-3011.
PMID: 36706021
Lipid interactions modulate the function, folding, structure, and organization of membrane proteins. Hydrogen/deuterium exchange mass spectrometry (HDX-MS) has emerged as a useful tool to understand the structural dynamics of these...
7.
Russell Lewis B, Lawrence R, Hammerschmid D, Reading E
Essays Biochem
. 2022 Dec;
67(2):255-267.
PMID: 36504255
Multidrug efflux pumps are ubiquitous across both eukaryotes and prokaryotes, and have major implications in antimicrobial and multidrug resistance. They reside within cellular membranes and have proven difficult to study...
8.
Harris N, Reading E, Booth P
Methods Mol Biol
. 2022 Jan;
2433:273-292.
PMID: 34985751
In order to comprehend the molecular basis of transmembrane protein biogenesis, methods are required that are capable of investigating the co-translational folding of these hydrophobic proteins. Equally, in artificial cell...
9.
Reading E, Ahdash Z, Fais C, Ricci V, Wang-Kan X, Grimsey E, et al.
Nat Commun
. 2020 Nov;
11(1):5565.
PMID: 33149158
Resistance-nodulation-division efflux pumps play a key role in inherent and evolved multidrug resistance in bacteria. AcrB, a prototypical member of this protein family, extrudes a wide range of antimicrobial agents...
10.
Jesin J, Stone T, Mitchell C, Reading E, Deber C
Biochemistry
. 2020 Oct;
59(41):3973-3981.
PMID: 33026802
Clinically relevant multidrug-resistant bacteria often arise due to overproduction of membrane-embedded efflux proteins that are capable of pumping antibiotics out of the bacterial cell before the drugs can exert their...