Author: E Yamauchi | MedLuna.com

1.

Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro

Konishi H, Yamauchi E, Taniguchi H, Yamamoto T, Matsuzaki H, Takemura Y, et al.

Proc Natl Acad Sci U S A . 2001 Jun; 98(12):6587-92. PMID: 11381116

Protein kinase C delta (PKC delta) is normally activated by diacylglycerol produced from receptor-mediated hydrolysis of inositol phospholipids. On stimulation of cells with H(2)O(2), the enzyme is tyrosine phosphorylated, with...

2.

Domain structure of tropomodulin: distinct properties of the N-terminal and C-terminal halves

Kostyukova A, Maeda K, Yamauchi E, Krieger I, Maeda Y

Eur J Biochem . 2000 Oct; 267(21):6470-5. PMID: 11029591

The structure of tropomodulin, the unique capping protein for the pointed end (the slow-growing end) of an actin filament, was studied. An improved Escherichia coli expression system for chicken E-tropomodulin...

3.

The pharmacokinetics of trinitroglycerin and its metabolites in patients with chronic stable angina

Hashimoto S, Yamauchi E, Kobayashi A, Shigemi K, Tsuruta H, Yamashita T, et al.

Br J Clin Pharmacol . 2000 Sep; 50(4):373-6. PMID: 11012561

Aims: To study the pharmacokinetics of trinitroglycerin (GTN) and its four metabolites in angina patients during their transient use of transdermal GTN tape following intravenous administration of GTN. Methods: Four...

4.

Identification of high-risk breast cancer patients from genetic changes of their tumors

Watatani M, Inui H, Nagayama K, Imanishi Y, Nishimura K, Hashimoto Y, et al.

Surg Today . 2000 Jul; 30(6):516-22. PMID: 10883462

To identify the genetic prognostic markers for breast cancer, we analyzed loss of heterozygosity (LOH) at 11p, 16q, 17p, 17q, and 18q, as well as amplification of the ERBB2, INT2,...

5.

Phosphorylation of the myristoylated protein kinase C substrate MARCKS by the cyclin E-cyclin-dependent kinase 2 complex in vitro

Manenti S, Yamauchi E, Sorokine O, Knibiehler M, Van Dorsselaer A, Taniguchi H, et al.

Biochem J . 1999 Jun; 340 ( Pt 3):775-82. PMID: 10359664

The myristoylated alanine-rich C-kinase substrate (MARCKS) purified from brain was recently characterized as a proline-directed kinase(s) substrate in vivo [Taniguchi, Manenti, Suzuki and Titani (1994) J. Biol. Chem. 269, 18299-18302]....

6.

Identification of the calmodulin-binding domain of neuron-specific protein kinase C substrate protein CAP-22/NAP-22. Direct involvement of protein myristoylation in calmodulin-target protein interaction

Takasaki A, Hayashi N, Matsubara M, Yamauchi E, Taniguchi H

J Biol Chem . 1999 Apr; 274(17):11848-53. PMID: 10207003

Various proteins in the signal transduction pathways as well as those of viral origin have been shown to be myristoylated. Although the modification is often essential for the proper functioning...

7.

Presence of conserved domains in the C-terminus of MARCKS, a major in vivo substrate of protein kinase C: application of ion trap mass spectrometry to the elucidation of protein structures

Yamauchi E, Kiyonami R, Kanai M, Taniguchi H

J Biochem . 1998 May; 123(4):760-5. PMID: 9538272

MARCKS, the major protein kinase C substrate in various cells and tissues, binds to calmodulin, acidic membrane phospholipids, and actin filaments, and these interactions are regulated by protein phosphorylation. We...

8.

The C-terminal conserved domain of MARCKS is phosphorylated in vivo by proline-directed protein kinase. Application of ion trap mass spectrometry to the determination of protein phosphorylation sites

Yamauchi E, Kiyonami R, Kanai M, Taniguchi H

J Biol Chem . 1998 Mar; 273(8):4367-71. PMID: 9468486

MARCKS, the major protein kinase C substrate in various cells and tissues, binds to calmodulin, acidic membrane phospholipids, and actin filaments, and these interactions are regulated by protein phosphorylation. We...

9.

MARCKS, a major protein kinase C substrate, assumes non-helical conformations both in solution and in complex with Ca2+-calmodulin

Matsubara M, Yamauchi E, Hayashi N, Taniguchi H

FEBS Lett . 1998 Feb; 421(3):203-7. PMID: 9468306

MARCKS, a major cellular substrate for protein kinase C, plays important roles in various cellular functions and its functions are regulated by calmodulin. We have studied the conformational properties of...

10.

Specific binding of acidic phospholipids to microtubule-associated protein MAP1B regulates its interaction with tubulin

Yamauchi E, Titani K, Taniguchi H

J Biol Chem . 1997 Sep; 272(36):22948-53. PMID: 9278459

Microtubule-associated protein MAP1B, a major neuronal cytoskeletal protein, is expressed highly during the early stage of brain development and is thought to play an important role in brain development. Although...