E T Kool
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Explore the profile of E T Kool including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
1108
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Recent Articles
1.
Diegelman A, Kool E
Curr Protoc Nucleic Acid Chem
. 2008 Apr;
Chapter 5:Unit 5.2.
PMID: 18428858
Small circular oligonucleotides can be used for diagnostic, therapeutic, and laboratory purposes. These systems have gained considerable attention in recent years because they form unusually strong and specific complexes with...
2.
Kool E
Cold Spring Harb Symp Quant Biol
. 2003 May;
65:93-102.
PMID: 12760024
No abstract available.
3.
Drotschmann K, Yang W, Brownewell F, Kool E, Kunkel T
J Biol Chem
. 2001 Oct;
276(49):46225-9.
PMID: 11641390
Crystal structures of bacterial MutS homodimers bound to mismatched DNA reveal asymmetric interactions of the two subunits with DNA. A phenylalanine and glutamate of one subunit make mismatched base-specific interactions,...
4.
Schofield M, Brownewell F, Nayak S, Du C, Kool E, Hsieh P
J Biol Chem
. 2001 Oct;
276(49):45505-8.
PMID: 11602569
The crystal structures of MutS protein from Thermus aquaticus and Escherichia coli in a complex with a mismatch-containing DNA duplex reveal that the Glu residue in a conserved Phe-X-Glu motif...
5.
Kool E
Annu Rev Biophys Biomol Struct
. 2001 May;
30:1-22.
PMID: 11340050
Understanding the mechanisms by which genetic information is replicated is important both to basic knowledge of biological organisms and to many useful applications in biomedical research and biotechnology. One of...
6.
Dzantiev L, Alekseyev Y, Morales J, Kool E, Romano L
Biochemistry
. 2001 Mar;
40(10):3215-21.
PMID: 11258938
DNA polymerases insert a dNTP by a multistep mechanism that involves a conformational rearrangement from an open to a closed ternary complex, a process that positions the incoming dNTP in...
7.
Xu Y, Karalkar N, Kool E
Nat Biotechnol
. 2001 Feb;
19(2):148-52.
PMID: 11175729
Enzymatic ligation methods are useful in diagnostic detection of DNA sequences. Here we describe the investigation of nonenzymatic phosphorothioate-iodide DNA autoligation chemistry as a method for detection and identification of...
8.
Kool E
Curr Opin Chem Biol
. 2000 Dec;
4(6):602-8.
PMID: 11102863
DNA polymerase enzymes process their natural substrates with very high specificity. Yet recent experiments have shown that these enzymes can also process DNA in which the backbone or bases are...
9.
Sun L, Wang M, Kool E, Taylor J
Biochemistry
. 2000 Nov;
39(47):14603-10.
PMID: 11087416
We recently proposed a mechanism for why dAMP is primarily inserted opposite both T's of photoproducts of TT sites by T7 DNA polymerase [Smith, C. A., Baeten, J., and Taylor,...
10.
Morales J, Kool E
Biochemistry
. 2000 Oct;
39(42):12979-88.
PMID: 11041863
Recent studies have identified amino acid side chains forming several hydrogen bonds in the DNA minor groove as potentially important in polymerase replication of DNA. Few studies have probed these...