E T Adman
Overview
Explore the profile of E T Adman including associated specialties, affiliations and a list of published articles.
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Articles
44
Citations
822
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Recent Articles
1.
Petra P, Adman E, Orr W, Woodcock K, Groff C, Sui L
Protein Sci
. 2001 Aug;
10(9):1811-21.
PMID: 11514672
Arginine-140 and isoleucine-141 were identified as key determinants of 17beta-estradiol (E(2)) binding affinity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma. Amino acid residues that differ between human...
2.
Adman E, Le Trong I, Stenkamp R, Nieslanik B, Dietze E, Tai G, et al.
Proteins
. 2000 Dec;
42(2):192-200.
PMID: 11119643
Twelve C-terminal residues of human glutathione S-transferase A1-1 form a helix in the presence of glutathione-conjugate, or substrate alone, and partly cover the active site. According to X-ray structures, the...
3.
Weiss K, Isaacs S, Tran N, Adman E, Kim B
Biochemistry
. 2000 Sep;
39(35):10684-94.
PMID: 10978152
Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is a putative source of the genomic hypermutation that promotes rapid evolution of HIV-1. To understand the molecular strategies that create...
4.
Suzuki M, Yoshida S, Adman E, Blank A, Loeb L
J Biol Chem
. 2000 Jul;
275(42):32728-35.
PMID: 10906120
Phe(667) in the conserved O-helix of Thermus aquaticus (Taq) DNA polymerase I (pol I) is known to be important for discrimination against dideoxy-NTPs. We show here that Phe(667) is also...
5.
Sandberg M, Hassett C, Adman E, Meijer J, Omiecinski C
J Biol Chem
. 2000 Jun;
275(37):28873-81.
PMID: 10862610
Human soluble epoxide hydrolase (sEH), an enzyme directing the functional disposition of a variety of endogenous and xenobiotic-derived chemical epoxides, was characterized at the genomic level for interindividual variation capable...
6.
Kim B, Ayran J, Sagar S, Adman E, Fuller S, Tran N, et al.
J Biol Chem
. 1999 Sep;
274(39):27666-73.
PMID: 10488107
Infidelity of DNA synthesis by human immunodeficiency virus, type 1 reverse transcriptase (HIV-1 RT) is a presumptive determinant of HIV-1 hypervariability and is incompletely understood at the mechanistic and structural...
7.
Landis D, Gerlach J, Adman E, Loeb L
Nucleic Acids Res
. 1999 Sep;
27(18):3702-11.
PMID: 10471740
Fluoropyrimidines, such as 5-fluorouracil (5-FU), are used extensively in cancer therapy. In the cell, 5-FU is metabolized to 5-fluorodeoxyuridylate (5-FdUMP), a tight binding covalent inhibitor of thymidylate synthase (TS). In...
8.
Kokoris M, Sabo P, Adman E, Black M
Gene Ther
. 1999 Sep;
6(8):1415-26.
PMID: 10467366
With the advent of gene therapy, herpes simplex virus type I (HSV-1) thymidine kinase (TK) has garnered much interest as a suicide gene for cancer ablation. As a means to...
9.
Muchowski P, Wu G, Liang J, Adman E, Clark J
J Mol Biol
. 1999 Jun;
289(2):397-411.
PMID: 10366513
Site-directed mutagenesis was used to evaluate the effects on structure and function of selected substitutions within and N-terminal to the core "alpha-crystallin" domain of the small heat-shock protein (sHsp) and...
10.
Sokal I, Haeseleer F, ARENDT A, Adman E, HARGRAVE P, Palczewski K
Biochemistry
. 1999 Feb;
38(5):1387-93.
PMID: 9931003
Regulation of cAMP and cGMP production is a fundamental step in a broad range of signal transduction systems, including phototransduction. To identify regions within photoreceptor guanylyl cyclase 1 (GC1) that...