E Nicholas Petersen
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Explore the profile of E Nicholas Petersen including associated specialties, affiliations and a list of published articles.
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8
Citations
286
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Recent Articles
1.
Petersen E, Pavel M, Hansen S, Gudheti M, Wang H, Yuan Z, et al.
Elife
. 2024 Feb;
12.
PMID: 38407149
Rapid conversion of force into a biological signal enables living cells to respond to mechanical forces in their environment. The force is believed to initially affect the plasma membrane and...
2.
Hansen S, Lerner R, Pavel M, Petersen E
Proc Natl Acad Sci U S A
. 2020 Sep;
117(40):24629.
PMID: 32994344
No abstract available.
3.
Pavel M, Petersen E, Wang H, Lerner R, Hansen S
Proc Natl Acad Sci U S A
. 2020 May;
117(24):13757-13766.
PMID: 32467161
Inhaled anesthetics are a chemically diverse collection of hydrophobic molecules that robustly activate TWIK-related K channels (TREK-1) and reversibly induce loss of consciousness. For 100 y, anesthetics were speculated to...
4.
Petersen E, Pavel M, Wang H, Hansen S
Biochim Biophys Acta Biomembr
. 2019 Nov;
1862(1):183091.
PMID: 31672538
TWIK related K+ channel (TREK-1) is a mechano- and anesthetic sensitive channel that when activated attenuates pain and causes anesthesia. Recently the enzyme phospholipase D2 (PLD2) was shown to bind...
5.
Pavel M, Chung H, Petersen E, Hansen S
Anesth Analg
. 2019 May;
129(4):973-982.
PMID: 31124840
Background: Local anesthetics cause reversible block of pain and robustly inhibit TWIK-related K channel (TREK-1) currents. Before local anesthesia onset, injection of local anesthetics can cause unwanted transient pain. TREK-1...
6.
Chung H, Petersen E, Cabanos C, Murphy K, Pavel M, Hansen A, et al.
J Mol Biol
. 2018 Dec;
431(2):196-209.
PMID: 30529033
Despite the widespread consumption of ethanol, mechanisms underlying its anesthetic effects remain uncertain. n-Alcohols induce anesthesia up to a specific chain length and then lose potency-an observation known as the...
7.
Petersen E, Chung H, Nayebosadri A, Hansen S
Nat Commun
. 2016 Dec;
7:13873.
PMID: 27976674
The sensing of physical force, mechanosensation, underlies two of five human senses-touch and hearing. How transduction of force in a membrane occurs remains unclear. We asked if a biological membrane...
8.
Woolstenhulme C, Parajuli S, Healey D, Valverde D, Petersen E, Starosta A, et al.
Proc Natl Acad Sci U S A
. 2013 Feb;
110(10):E878-87.
PMID: 23431150
Although the ribosome is a very general catalyst, it cannot synthesize all protein sequences equally well. For example, ribosomes stall on the secretion monitor (SecM) leader peptide to regulate expression...