E M Schaefer
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Explore the profile of E M Schaefer including associated specialties, affiliations and a list of published articles.
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14
Citations
230
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Recent Articles
1.
Schaller M, Schaefer E
Biochem J
. 2001 Nov;
360(Pt 1):57-66.
PMID: 11695992
Paxillin is a focal-adhesion-associated, tyrosine-phosphorylated protein. In cells transformed by the src, crk or BCR-Abl oncogenes, the phosphotyrosine content of paxillin is elevated. In normal cells paxillin functions in signalling...
2.
Ilic D, Genbacev O, Jin F, Caceres E, Almeida E, Schaefer E, et al.
Am J Pathol
. 2001 Jul;
159(1):93-108.
PMID: 11438458
During human pregnancy specialized placental cells of fetal origin, termed cytotrophoblasts, invade the uterus and its blood vessels. This tumor-like process anchors the conceptus to the mother and diverts the...
3.
Lyons P, Dunty J, Schaefer E, Schaller M
J Biol Chem
. 2001 May;
276(26):24422-31.
PMID: 11337490
Protein-tyrosine phosphatase (PTP)-PEST is a cytoplasmic tyrosine phosphatase that can bind and dephosphorylate the focal adhesion-associated proteins p130(CAS) and paxillin. Focal adhesion kinase (FAK) and cell adhesion kinase beta (CAKbeta)/PYK2/CADTK/RAFTK...
4.
A novel mitogen-activated protein kinase is responsive to Raf and mediates growth factor specificity
Janulis M, Trakul N, Greene G, Schaefer E, Lee J, Rosner M
Mol Cell Biol
. 2001 Mar;
21(6):2235-47.
PMID: 11238956
The proto-oncogene Raf is a major regulator of growth and differentiation. Previous studies from a number of laboratories indicate that Raf activates a signaling pathway that is independent of the...
5.
Ma A, Richardson A, Schaefer E, Parsons J
Mol Biol Cell
. 2001 Feb;
12(1):1-12.
PMID: 11160818
Focal adhesion kinase (FAK) is an important regulator of integrin signaling in adherent cells and accordingly its activity is significantly modulated during mitosis when cells detach from the extracellular matrix....
6.
The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation
Wennerberg K, Armulik A, Sakai T, Karlsson M, Fassler R, Schaefer E, et al.
Mol Cell Biol
. 2000 Jul;
20(15):5758-65.
PMID: 10891511
We have previously shown that mutation of the two tyrosines in the cytoplasmic domain of integrin subunit beta1 (Y783 and Y795) to phenylalanines markedly reduces the capability of beta1A integrins...
7.
Schaefer E, Guimond S
Anal Biochem
. 1998 Jul;
261(1):100-12.
PMID: 9683518
A protein tyrosine kinase (PTK) assay system is described that uses a series of optimized biotinylated peptide substrates in conjunction with a streptavidin-coated matrix (SAM(2)) biotin capture membrane. The SAM(2)...
8.
Walton K, DiRocco R, Bartlett B, Koury E, Marcy V, Jarvis B, et al.
J Neurochem
. 1998 Apr;
70(4):1764-7.
PMID: 9523596
p38MAPK has been implicated in the regulation of proinflammatory cytokines and apoptosis in vitro. To understand its role in neurodegeneration, we determined the time course and localization of the dually...
9.
Xu S, Khoo S, Dang A, Witt S, Do V, Zhen E, et al.
Mol Endocrinol
. 1997 Nov;
11(11):1618-25.
PMID: 9328344
Mitogen-activated protein (MAP)/ERK kinase (MEK)1 and MEK2 are the upstream activators of the MAP kinases, ERK1 and ERK2. MEK1 and MEK2 are approximately 85% identical in sequence but have unique...
10.
Schaefer E, Viard V, Morin J, Ferre P, Penicaud L, Ramos P, et al.
Diabetes
. 1994 Jan;
43(1):143-53.
PMID: 7505243
Expression under the control of the mouse transferrin promoter of a transgene encoding a soluble secreted derivative of the ectodomain of the human insulin receptor in transgenic mice results in...