E J Steele
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Explore the profile of E J Steele including associated specialties, affiliations and a list of published articles.
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55
Citations
342
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Recent Articles
11.
Zylstra P, Rothenfluh H, Weiller G, Blanden R, Steele E
Immunol Cell Biol
. 1998 Nov;
76(5):395-405.
PMID: 9797458
Murine immunoglobulin germline V genes exist as multiple sequences arranged in tandem in germline DNA. Because members of V gene families are very similar, they can be amplified simultaneously using...
12.
Blanden R, Steele E
Immunol Cell Biol
. 1998 Jul;
76(3):288-93.
PMID: 9682973
We have reviewed available data concerning the mechanism of somatic hypermutation in rearranged variable genes of Ig in B lymphocytes of mice and the gene conversion process which generates diversity...
13.
Weiller G, Rothenfluh H, Zylstra P, Gay L, Averdunk H, Steele E, et al.
Immunol Cell Biol
. 1998 Jun;
76(2):179-85.
PMID: 9619489
In human and mouse, the germline contains a tandem array of highly homologous variable (V) gene elements which encode part of the antigen-binding region of the antibody protein. During evolution...
14.
Blanden R, Rothenfluh H, Zylstra P, Weiller G, Steele E
Immunol Rev
. 1998 May;
162:117-32.
PMID: 9602358
We present here a unifying hypothesis for the molecular mechanism of somatic hypermutation and somatic gene conversion in IgV genes involving reverse transcription using RNA templates from the V-gene loci...
15.
Blanden R, Rothenfluth H, Steele E
Curr Top Microbiol Immunol
. 1998 Feb;
229:21-32.
PMID: 9479845
No abstract available.
16.
Steele E, Rothenfluh H, Blanden R
Immunol Cell Biol
. 1997 Feb;
75(1):82-95.
PMID: 9046438
Available data relevant to the mechanism of somatic hypermutation have been critically evaluated in the context of alternative models: (i) error-generating reverse transcription (RT) followed by homologous recombination; and (ii)...
17.
Rothenfluh H, Blanden R, Steele E
Immunogenetics
. 1995 Jan;
42(3):159-71.
PMID: 7642227
In this review we have examined the features of germline sequences of IgV genes from a number of species in an attempt to identify the "signature" of molecular mechanisms responsible...
18.
Rothenfluh H, GIBBS A, Blanden R, Steele E
Proc Natl Acad Sci U S A
. 1994 Dec;
91(25):12163-7.
PMID: 7991601
We analyzed the DNA sequence structure of the 5' flanking and coding regions of 52 VH186.2-related germ-line genes isolated by PCR from C57BL/6J and BALB/c mice. The aligned coding regions...
19.
Steele E, Rothenfluh H, Ada G, Blanden R
Immunol Rev
. 1993 Oct;
135:5-49.
PMID: 8282316
In this review we have re-evaluated the dominant paradigm that TcR V genes do not somatically mutate. We highlight the many structural and functional similarities between Ig and TcR antigen-specific...
20.
Rothenfluh H, Taylor L, Bothwell A, Both G, Steele E
Eur J Immunol
. 1993 Sep;
23(9):2152-9.
PMID: 8370398
The aim of this study has been to determine the distribution of somatic mutations in the 5' flanking regions of rearranged immunoglobulin heavy chain variable region genes (VDJ). We sequenced...