E Georges
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Explore the profile of E Georges including associated specialties, affiliations and a list of published articles.
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53
Citations
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Recent Articles
1.
Karwatsky J, Georges E
Curr Med Chem Anticancer Agents
. 2004 Feb;
4(1):19-30.
PMID: 14754409
Drug resistance is a major impediment in the treatment of cancer patients receiving single or multiple drug treatment. Efforts to reverse drug resistance of tumor cells have not been successful....
2.
Cai J, Daoud R, Georges E, Gros P
Biochemistry
. 2001 Jul;
40(28):8307-16.
PMID: 11444977
Overexpression of the multidrug resistance-associated protein (MRP1) causes multidrug resistance in cultured cells. MRP1 transports a large number of glutathione, glucuronide, and sulfate-conjugated organic anions by an ATP-dependent efflux mechanism....
3.
Daoud R, Julien M, Gros P, Georges E
J Biol Chem
. 2001 Jan;
276(15):12324-30.
PMID: 11152467
MRP1 is an ABC (or ATP binding cassette) membrane transport protein shown to confer resistance to structurally dissimilar drugs. Studies of MRP1 topology suggested the presence of a hydrophobic N-domain...
4.
Daoud R, Kast C, Gros P, Georges E
Biochemistry
. 2000 Dec;
39(50):15344-52.
PMID: 11112520
The mechanisms of MRP1-drug binding and transport are not clear. In this study, we have characterized the interaction between MRP1 and rhodamine 123 (Rh123) using the photoreactive-iodinated analogue, [(125)I]iodoaryl azido-rhodamine...
5.
Daoud R, Desneves J, Deady L, Tilley L, Scheper R, Gros P, et al.
Biochemistry
. 2000 May;
39(20):6094-102.
PMID: 10821682
Tumor cells overcome cytotoxic drug pressure by the overexpression of either or both transmembrane proteins, the P-glycoprotein (P-gp) and the multidrug resistance protein (MRP). The MRP has been shown to...
6.
Vezmar M, Georges E
Biochem Pharmacol
. 2000 Mar;
59(10):1245-52.
PMID: 10736425
The overexpression of P-glycoprotein (P-gp) and the multidrug resistance-associated protein (MRP) have been shown to confer broad drug resistance in tumor cells. We have demonstrated previously direct binding between MRP...
7.
Abrahem A, Certad G, Pan X, Georges E
Biochem Pharmacol
. 2000 Mar;
59(9):1123-32.
PMID: 10704942
The development and spread of multidrug-resistant Plasmodium falciparum are major health concerns. The molecular mechanisms of multidrug resistance, including resistance to many quinoline-based antimalarials, are largely unknown. In this study,...
8.
Certad G, Abrahem A, Georges E
Exp Parasitol
. 1999 Oct;
93(3):123-31.
PMID: 10529354
Certad, G., Abrahem, A., and Georges, E. 1999. Cloning and Partial characterization of the proteasome S4 ATPase from Plasmodium falciparum. Experimental Parasitology 93, 123-131. The ATP-ubiquitin-proteasome pathway mediates the nonlysosomal...
9.
Rabaud C, Georges E, Guedenet J, Allamagny E, May T, Canton P
Pathol Biol (Paris)
. 1999 Jul;
47(5):576-8.
PMID: 10418045
An HIV-positive patient developed disseminated Enterocytozoon bieneusi infection. The parasite was identified in stool, duodenal biopsy, nasal discharge, and sputum specimens using transmission electron microscopy. Albendazole therapy failed to improve...
10.
Georges E, Rabaud C, Amiel C, Kures L, Guedenet J, Allamagny E, et al.
J Infect
. 1998 Nov;
36(2):223-5.
PMID: 9570660
Multiorgan microsporidiosis due to Enterocytozoon bieneusi was diagnosed in an HIV-infected patient. The parasite was found and identified as E. bieneusi by transmission electron microscopy in stools, duodenal biopsy, nasal...