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E Georg Luebeck

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Recent Articles
1.
Dai J, Georg Luebeck E, Chang E, Clarke C, Hubbell E, Zhang N, et al.
J Med Screen . 2024 May; 31(4):211-222. PMID: 38797981
Background: Late-stage cancer incidence has been proposed as an early surrogate for mortality in randomized controlled trials (RCTs) of cancer screening; however, its validity has not been systematically evaluated across...
2.
Moolgavkar S, Chang E, Georg Luebeck E
Environ Res . 2023 Mar; 230:114582. PMID: 36965799
The current paradigm of carcinogenesis as a cellular evolutionary process driven by mutations of a few critical driver genes has immediate logical implications for the epidemiology of cancer. These include...
3.
Georg Luebeck E, Curtius K, Hazelton W, Maden S, Yu M, Thota P, et al.
Clin Epigenetics . 2017 Oct; 9:113. PMID: 29046735
Background: Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that is called epigenetic drift. However, the evolving patterns, functional consequences,...
4.
Heberle C, Omidvari A, Ali A, Kroep S, Kong C, Inadomi J, et al.
Clin Gastroenterol Hepatol . 2017 Feb; 15(9):1397-1404.e7. PMID: 28238953
Background & Aims: It is important to identify patients with Barrett's esophagus (BE), the precursor to esophageal adenocarcinoma (EAC). Patients with BE usually are identified by endoscopy, which is expensive....
5.
Kroep S, Heberle C, Curtius K, Kong C, Lansdorp-Vogelaar I, Ali A, et al.
Clin Gastroenterol Hepatol . 2017 Jan; 15(9):1471-1474. PMID: 28089850
No abstract available.
6.
Yankeelov T, An G, Saut O, Georg Luebeck E, Popel A, Ribba B, et al.
Ann Biomed Eng . 2016 Jul; 44(9):2626-41. PMID: 27384942
Hierarchical processes spanning several orders of magnitude of both space and time underlie nearly all cancers. Multi-scale statistical, mathematical, and computational modeling methods are central to designing, implementing and assessing...
7.
Curtius K, Wong C, Hazelton W, Kaz A, Chak A, Willis J, et al.
PLoS Comput Biol . 2016 May; 12(5):e1004919. PMID: 27168458
Biomarkers that drift differentially with age between normal and premalignant tissues, such as Barrett's esophagus (BE), have the potential to improve the assessment of a patient's cancer risk by providing...
8.
Curtius K, Hazelton W, Jeon J, Georg Luebeck E
PLoS Comput Biol . 2015 May; 11(5):e1004272. PMID: 26001209
Barrett's esophagus (BE) patients are routinely screened for high grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) through endoscopic screening, during which multiple esophageal tissue samples are removed for histological analysis....
9.
Hazelton W, Curtius K, Inadomi J, Vaughan T, Meza R, Rubenstein J, et al.
Cancer Epidemiol Biomarkers Prev . 2015 May; 24(7):1012-23. PMID: 25931440
Background: U.S. esophageal adenocarcinoma (EAC) incidence increased over 5-fold between 1975 and 2009. Symptomatic gastroesophageal reflux disease (sGERD) elevates the risk for EAC. However, a simple calculation suggests that changes...
10.
Jeon J, Meza R, Hazelton W, Renehan A, Georg Luebeck E
Cancer Causes Control . 2015 Mar; 26(6):859-70. PMID: 25783458
Purpose: Screening colonoscopy and flexible sigmoidoscopy (FSG) reduce the risk of colorectal cancer (CRC), but the magnitude and duration of protection, particularly against right-sided cancer, remain uncertain. We computed the...