E E Howell
Overview
Explore the profile of E E Howell including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
335
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Recent Articles
1.
SMILEY R, Saxton A, Jackson M, Hicks S, Stinnett L, Howell E
Anal Biochem
. 2004 Oct;
334(1):204-6.
PMID: 15464972
No abstract available.
2.
Howell E, Shukla U, Hicks S, SMILEY R, Kuhn L, Zavodszky M
J Comput Aided Mol Des
. 2002 May;
15(11):1035-52.
PMID: 11989624
R67 dihydrofolate reductase (DHFR) is a novel enzyme that confers resistance to the antibiotic trimethoprim. The crystal structure of R67 DHFR displays a toroidal structure with a central active-site pore....
3.
SMILEY R, Hicks S, Stinnett L, Howell E, Saxton A
Anal Biochem
. 2002 Jan;
301(1):153-6.
PMID: 11811980
No abstract available.
4.
Strader M, SMILEY R, Stinnett L, VerBerkmoes N, Howell E
Biochemistry
. 2001 Sep;
40(38):11344-52.
PMID: 11560482
R67 dihydrofolate reductase (DHFR) shares no sequence or structural homology with chromosomal DHFRs. This enzyme arose recently in response to the clinical use of the antibacterial drug trimethoprim. R67 DHFR...
5.
Li D, LEVY L, Gabel S, Lebetkin M, DeRose E, Wall M, et al.
Biochemistry
. 2001 Apr;
40(14):4242-52.
PMID: 11284680
R67 dihydrofolate reductase (DHFR) is a type II DHFR produced by bacteria as a resistance mechanism to the increased clinical use of the antibacterial drug trimethoprim. Type II DHFRs are...
6.
West F, Seo H, Bradrick T, Howell E
Biochemistry
. 2000 Mar;
39(13):3678-89.
PMID: 10736167
R67 dihydrofolate reductase (DHFR) is an R-plasmid-encoded enzyme that confers clinical resistance to the antibacterial drug trimethoprim. This enzyme shows no sequence or structural homology to the chromosomal DHFRs. The...
7.
Howell E, Bathon J
Md Med J
. 2000 Jan;
48(6):292-4.
PMID: 10628129
Reactive arthritis is a term used to describe a sterile inflammatory arthritis occurring after a documented infection elsewhere in the body. Group A streptococcus is known to cause such an...
8.
Park H, Bradrick T, Howell E
Protein Eng
. 1998 May;
10(12):1415-24.
PMID: 9543003
R67 dihydrofolate reductase (DHFR) is a type II DHFR produced by bacteria as a resistance mechanism to increasing clinical use of the antibacterial drug trimethoprim. Type II DHFRs are not...
9.
Howell E
Protein Eng
. 1997 Mar;
10(3):263-72.
PMID: 9153076
The role of a beta-bulge in Escherichia coli dihydrofolate reductase (DHFR) has been explored by a series of insertion and deletion mutations. Insertion of a seven amino acid sequence from...
10.
Park H, Zhuang P, Nichols R, Howell E
J Biol Chem
. 1997 Jan;
272(4):2252-8.
PMID: 8999931
R67 dihydrofolate reductase (DHFR) is encoded by an R-plasmid, and expression of this enzyme in bacteria confers resistance to the antibacterial drug, trimethoprim. This DHFR variant is not homologous in...