E Comets
Overview
Explore the profile of E Comets including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
402
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Recent Articles
1.
Toumazi A, Comets E, Alberti C, Friede T, Lentz F, Stallard N, et al.
Comput Methods Programs Biomed
. 2018 Feb;
157:163-177.
PMID: 29477425
Background And Objective: Dose-finding, aiming at finding the maximum tolerated dose, and pharmacokinetics studies are the first in human studies in the development process of a new pharmacological treatment. In...
2.
Cerou M, Lavielle M, Brendel K, Chenel M, Comets E
Pharm Res
. 2018 Jan;
35(2):30.
PMID: 29368033
Purpose: Normalised prediction distribution errors (npde) are used to graphically and statistically evaluate mixed-effect models for continuous responses. In this study, our aim was to extend npde to time-to-event (TTE)...
3.
Bizzotto R, Comets E, Smith G, Yvon F, Kristensen N, Swat M
CPT Pharmacometrics Syst Pharmacol
. 2017 Jun;
6(10):651-665.
PMID: 28575551
PharmML is an XML-based exchange format created with a focus on nonlinear mixed-effect (NLME) models used in pharmacometrics, but providing a very general framework that also allows describing mathematical and...
4.
Nguyen T, Mouksassi M, Holford N, Al-Huniti N, Freedman I, Hooker A, et al.
CPT Pharmacometrics Syst Pharmacol
. 2016 Nov;
6(2):87-109.
PMID: 27884052
This article represents the first in a series of tutorials on model evaluation in nonlinear mixed effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model Evaluation Group. Numerous...
5.
Tessier A, Bertrand J, Chenel M, Comets E
CPT Pharmacometrics Syst Pharmacol
. 2016 Apr;
5(3):123-31.
PMID: 27069775
We show through a simulation study how the joint analysis of data from phase I and phase II studies enhances the power of pharmacogenetic tests in pharmacokinetic (PK) studies. PK...
6.
Swat M, Moodie S, Wimalaratne S, Kristensen N, Lavielle M, Mari A, et al.
CPT Pharmacometrics Syst Pharmacol
. 2015 Jul;
4(6):316-9.
PMID: 26225259
The lack of a common exchange format for mathematical models in pharmacometrics has been a long-standing problem. Such a format has the potential to increase productivity and analysis quality, simplify...
7.
Gregoire N, Mimoz O, Megarbane B, Comets E, Chatelier D, Lasocki S, et al.
Antimicrob Agents Chemother
. 2014 Oct;
58(12):7324-30.
PMID: 25267662
Colistin is an old antibiotic that has recently gained a considerable renewal of interest as the last-line defense therapy against multidrug-resistant Gram-negative bacteria. It is administered as colistin methanesulfonate (CMS),...
8.
Mentre F, Chenel M, Comets E, Grevel J, Hooker A, Karlsson M, et al.
CPT Pharmacometrics Syst Pharmacol
. 2013 Jul;
2:e46.
PMID: 23887744
No abstract available.
9.
Vlasakakis G, Comets E, Keunecke A, Gueorguieva I, Magni P, Terranova N, et al.
CPT Pharmacometrics Syst Pharmacol
. 2013 Jul;
2:e40.
PMID: 23887723
Pharmaceutical sciences experts and regulators acknowledge that pharmaceutical development as well as drug usage requires more than scientific advancements to cope with current attrition rates/therapeutic failures. Drug disease modeling and...
10.
Comets E, Diquet B, Legrain S, Huisse M, Godon A, Bruhat C, et al.
Clin Pharmacol Ther
. 2012 Apr;
91(5):777-86.
PMID: 22472992
In the PREPA observational study, we investigated the factors influencing pharmacokinetic and pharmacodynamic variability in the responses to fluindione, an oral anticoagulant drug, in a general population of octogenarian inpatients.Measurements...