E A HARPER
Overview
Explore the profile of E A HARPER including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
114
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Recent Articles
1.
HARPER E, Roberts S, Kalindjian S
Br J Pharmacol
. 2007 Jun;
151(8):1352-67.
PMID: 17592503
Background And Purpose: Several studies using radioligand binding assays, have shown that measurement of thermodynamic parameters can allow discrimination of agonists and antagonists (Weiland et al., 1979; Borea et al.,...
2.
HARPER E, Black J
Br J Pharmacol
. 2007 Apr;
151(4):504-17.
PMID: 17401438
Background And Purpose: Studies suggest that measurement of thermodynamic parameters can allow discrimination of agonists and antagonists. Here we investigate whether agonists and antagonists can be thermodynamically discriminated at histamine...
3.
HARPER E, Shankley N, Black J
Br J Pharmacol
. 2007 Mar;
151(1):128-43.
PMID: 17351664
Background And Purpose: Agonist apparent affinities (pK(I)') in histamine H(3)-receptor binding assays were higher than expected from apparent affinity values (pK(app)) estimated in bioassay. Here, we investigate whether the degree...
4.
Coleman J, Kopke R, Liu J, Ge X, HARPER E, Jones G, et al.
Hear Res
. 2006 Oct;
226(1-2):104-13.
PMID: 17023129
Despite the use of hearing protection devices (HPDs) and engineering changes designed to improve workspaces, noise-induced hearing loss continues to be one of the most common and expensive disabilities in...
5.
Morton M, HARPER E, Tavares I, Shankley N
Br J Pharmacol
. 2003 Sep;
140(1):218-24.
PMID: 12967952
(1) The alternatively spliced, short and long cholecystokinin receptors (CCK2S and CCK2L) were expressed in NIH3T3 cells, and compared using radioligand-binding assays with identical buffer and incubation conditions. (2) As...
6.
Hasseldine A, HARPER E, Black J
Br J Pharmacol
. 2003 Apr;
138(7):1358-66.
PMID: 12711637
1. Left atrial strips from transgenic (TG4) mice with cardiac-specific overexpression ( approximately 200-fold) of the beta(2) adrenoceptor (beta(2)AR) were isolated, and their isometric force of contraction (F(c)) in response...
7.
Morton M, HARPER E, Tavares I, Shankley N
Br J Pharmacol
. 2002 Jul;
136(6):873-82.
PMID: 12110612
1. The pharmacology of the cholecystokinin CCK(1) receptors endogenously expressed in human gallbladder and human ascending colon smooth muscle tissue was compared using radioligand binding assays. 2. Saturation analysis of...
8.
HARPER E, Lovenberg T, Shankley N, Black J
Inflamm Res
. 2001 Jun;
50 Suppl 2:S106-7.
PMID: 11411576
No abstract available.
9.
Linney I, Buck I, HARPER E, Kalindjian S, Pether M, Shankley N, et al.
J Med Chem
. 2000 Jul;
43(12):2362-70.
PMID: 10882362
Novel, potent, and selective non-imidazole histamine H(3) receptor antagonists have been prepared based on the low-affinity ligand dimaprit (pK(I) 7.32 +/- 0.12, pK(B) 5.93 +/- 0.17). Detailed structure-activity studies have...
10.
HARPER E, Shankley N, Black J
Br J Pharmacol
. 1999 Nov;
128(4):881-90.
PMID: 10556922
1 We have investigated the binding of a novel histamine H3-receptor antagonist radioligand, [3H]- clobenpropit ([3H]-VUF9153), to guinea-pig cerebral cortex membranes. 2 Saturation isotherms for [3H]-clobenpropit appeared biphasic. Scatchard plots...