Dustin R Middleton
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Explore the profile of Dustin R Middleton including associated specialties, affiliations and a list of published articles.
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13
Citations
187
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Recent Articles
1.
Ozdilek A, Huang J, Babb R, Paschall A, Middleton D, Duke J, et al.
mBio
. 2021 Jun;
12(3):e0080021.
PMID: 34061603
Capsular polysaccharides (CPSs) are major virulence factors that decorate the surfaces of many human bacterial pathogens. In their pure form or as glycoconjugate vaccines, CPSs are extensively used in vaccines...
2.
Becken B, Davey L, Middleton D, Mueller K, Sharma A, Holmes Z, et al.
mBio
. 2021 May;
12(3).
PMID: 34006653
The mucophilic anaerobic bacterium is a prominent member of the gastrointestinal (GI) microbiota and the only known species of the phylum in the mammalian gut. A high prevalence of in...
3.
Middleton D, Aceil J, Seema Mustafa , Paschall A, Avci F
J Bacteriol
. 2021 Jan;
203(7).
PMID: 33468592
The pneumococcal serine-rich repeat protein (PsrP) is a high-molecular-weight, glycosylated adhesin that promotes the attachment of to host cells. PsrP, its associated glycosyltransferases (GTs), and dedicated secretion machinery are encoded...
4.
Paschall A, Middleton D, Wantuch P, Avci F
Pharm Res
. 2020 Nov;
37(12):236.
PMID: 33140159
Purpose: Streptococcus pneumoniae (Spn) serotype 3 (Spn3) is considered one of the most virulent serotypes with resistance to conventional vaccine and treatment regimens. Pn3Pase is a glycoside hydrolase that we...
5.
Sun L, Paschall A, Middleton D, Ishihara M, Ozdilek A, Wantuch P, et al.
Nat Commun
. 2020 May;
11(1):2550.
PMID: 32439962
The inherent molecular complexity of human pathogens requires that mammals evolved an adaptive immune system equipped to handle presentation of non-conventional MHC ligands derived from disease-causing agents, such as HIV-1...
6.
Paschall A, Middleton D, Avci F
J Vis Exp
. 2019 Apr;
(146).
PMID: 31009013
A key aspect of the immune response to bacterial colonization of the host is phagocytosis. An opsonophagocytic killing assay (OPKA) is an experimental procedure in which phagocytic cells are co-cultured...
7.
Cheng S, Wantuch P, Kizer M, Middleton D, Wang R, DiBello M, et al.
Org Biomol Chem
. 2019 Feb;
17(10):2646-2650.
PMID: 30778481
Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a...
8.
Sun L, Ishihara M, Middleton D, Tiemeyer M, Avci F
J Biol Chem
. 2018 Aug;
293(39):15178-15194.
PMID: 30115684
The glycan shield on the envelope glycoprotein gp120 of HIV-1 has drawn immense attention as a vulnerable site for broadly neutralizing antibodies and for its significant impact on host adaptive...
9.
Middleton D, Paschall A, Duke J, Avci F
Infect Immun
. 2018 Jun;
86(8).
PMID: 29866907
Despite a century of investigation, remains a major human pathogen, causing a number of diseases, such as pneumonia, meningitis, and otitis media. Like many encapsulated pathogens, the capsular polysaccharide (CPS)...
10.
Middleton D, Zhang X, Wantuch P, Ozdilek A, Liu X, LoPilato R, et al.
Glycobiology
. 2017 Dec;
28(2):90-99.
PMID: 29190349
Bacillus circulans Jordan 32352 was isolated from decaying organic matter in the New Jersey soil in the early 1930s. This soil-dwelling bacterium produced an enzyme capable of degrading the type...