Dustin C Frost
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Explore the profile of Dustin C Frost including associated specialties, affiliations and a list of published articles.
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19
Citations
271
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Recent Articles
1.
Zuniga N, Frost D, Kuhn K, Shin M, Whitehouse R, Wei T, et al.
J Proteome Res
. 2024 Oct;
23(11):5153-5165.
PMID: 39380184
Mass spectrometry-based sample multiplexing with isobaric tags permits the development of high-throughput and precise quantitative biological assays with proteome-wide coverage and minimal missing values. Here, we nearly doubled the multiplexing...
2.
Han S, Li Z, Shi Y, Cui Y, Huang J, Frost D, et al.
Anal Chem
. 2024 Feb;
96(9):3870-3878.
PMID: 38373348
Gut microbiota can regulate host brain functions and influence various physiological and pathological processes through the brain-gut axis. To systematically elucidate the intervention of different gut environments on different brain...
3.
Pavek J, Frey B, Frost D, Gu T, Li L, Smith L
Anal Chem
. 2023 Oct;
95(41):15245-15253.
PMID: 37791746
Top-down proteomics, the tandem mass spectrometric analysis of intact proteoforms, is the dominant method for proteoform characterization in complex mixtures. While this strategy produces detailed molecular information, it also requires...
4.
Liu R, Wei P, Keller C, Orefice N, Shi Y, Li Z, et al.
Anal Chem
. 2020 Sep;
92(20):14021-14030.
PMID: 32926775
Gut microbiota can regulate host physiological and pathological status through gut-brain communications or pathways. However, the impact of the gut microbiome on neuropeptides and proteins involved in regulating brain functions...
5.
Zhong X, Lietz C, Shi X, Buchberger A, Frost D, Li L
Anal Chim Acta
. 2020 Aug;
1127:163-173.
PMID: 32800120
Restenosis, re-narrowing of arterial lumen following intervention for cardiovascular disease, remains a major issue limiting the long-term therapeutic efficacy of treatment. The signaling molecules, TGFβ (transforming growth factor-beta) and Smad3,...
6.
Zhong X, Frost D, Yu Q, Li M, Gu T, Li L
Anal Chem
. 2020 Jul;
92(16):11119-11126.
PMID: 32649829
The unbiased selection of peptide precursors makes data-independent acquisition (DIA) an advantageous alternative to data-dependent acquisition (DDA) for discovery proteomics, but traditional multiplexed quantification approaches employing mass difference labeling or...
7.
Frost D, Feng Y, Li L
Anal Chem
. 2020 May;
92(12):8228-8234.
PMID: 32401496
Isobaric tags enable multiplexed quantitative analysis of many biological samples in a single LC-MS/MS experiment. As a cost-effective alternative to expensive commercial isobaric tagging reagents, we developed our own custom...
8.
Zhong X, Frost D, Li L
Anal Chem
. 2019 May;
91(13):7991-7995.
PMID: 31135137
A mass defect-based labeling strategy provides high accuracy as an MS-centric quantification method, avoiding the ratio compression that affects isobaric label-based reporter ion quantification. We have developed cost-effective 5-plex mass...
9.
Feng Y, Chen B, Yu Q, Zhong X, Frost D, Ikonomidou C, et al.
Anal Chem
. 2019 Jan;
91(4):3141-3146.
PMID: 30649853
Glycans are highly complex entities with multiple building units and different degrees of branched polymerization. Intensive research efforts have been directed to mass spectrometry (MS)-based qualitative and quantitative glycomic analysis...
10.
Zhong X, Yu Q, Ma F, Frost D, Lu L, Chen Z, et al.
Anal Chem
. 2019 Jan;
91(3):2112-2119.
PMID: 30608134
Absolute quantification in targeted proteomics is challenging due to a variety of factors, including low specificity in complex backgrounds, limited analytical throughput, and wide dynamic range. To address these problems,...