Dusana Majera
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Explore the profile of Dusana Majera including associated specialties, affiliations and a list of published articles.
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12
Citations
467
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Recent Articles
1.
Loffelmann M, Skrott Z, Majera D, Starha P, Krystof V, Mistrik M
Eur J Med Chem
. 2023 Sep;
261:115790.
PMID: 37690264
Dithiocarbamates (DTCs) are simple organic compounds with many applications in industry and medicine. They are potent metal chelators forming complexes with various metal ions, including copper. Recently, bis(diethyldithiocarbamate)-copper complex (CuET)...
2.
Majera D, Mistrik M
Int J Mol Sci
. 2020 Dec;
21(24).
PMID: 33322336
Survivin, as an antiapoptotic protein often overexpressed in cancer cells, is a logical target for potential cancer treatment. By overexpressing survivin, cancer cells can avoid apoptotic cell death and often...
3.
Majera D, Skrott Z, Chroma K, Merchut-Maya J, Mistrik M, Bartek J
Cells
. 2020 Feb;
9(2).
PMID: 32085572
Research on repurposing the old alcohol-aversion drug disulfiram (DSF) for cancer treatment has identified inhibition of NPL4, an adaptor of the p97/VCP segregase essential for turnover of proteins involved in...
4.
Skrott Z, Majera D, Gursky J, Buchtova T, Hajduch M, Mistrik M, et al.
Oncogene
. 2019 Aug;
38(40):6711-6722.
PMID: 31391554
Aldehyde dehydrogenase (ALDH) is a proposed biomarker and possible target to eradicate cancer stem cells. ALDH inhibition as a treatment approach is supported by anti-cancer effects of the alcohol-abuse drug...
5.
Vancurova M, Hanzlikova H, Knoblochova L, Kosla J, Majera D, Mistrik M, et al.
DNA Repair (Amst)
. 2019 Apr;
78:114-127.
PMID: 31009828
The bulk of DNA damage caused by ionizing radiation (IR) is generally repaired within hours, yet a subset of DNA lesions may persist even for long periods of time. Such...
6.
Majera D, Skrott Z, Bouchal J, Bartkova J, Simkova D, Gachechiladze M, et al.
Prostate
. 2018 Dec;
79(4):352-362.
PMID: 30499118
Background: Castration-resistant prostate cancer (PCa) represents a serious health challenge. Based on mechanistically-supported rationale we explored new therapeutic options based on clinically available drugs with anticancer effects, including inhibitors of...
7.
Skrott Z, Mistrik M, Andersen K, Friis S, Majera D, Gursky J, et al.
Nature
. 2017 Dec;
552(7684):194-199.
PMID: 29211715
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug...
8.
Kurfurstova D, Bartkova J, Vrtel R, Mickova A, Burdova A, Majera D, et al.
Mol Oncol
. 2016 Mar;
10(6):879-94.
PMID: 26987799
The DNA damage checkpoints provide an anti-cancer barrier in diverse tumour types, however this concept has remained unexplored in prostate cancer (CaP). Furthermore, targeting DNA repair defects by PARP1 inhibitors...
9.
Mistrik M, Vesela E, Furst T, Hanzlikova H, Frydrych I, Gursky J, et al.
Sci Rep
. 2016 Jan;
6:19567.
PMID: 26777522
Laser micro-irradiation is a technology widely used in the DNA damage response, checkpoint signaling, chromatin remodeling and related research fields, to assess chromatin modifications and recruitment of diverse DNA damage...
10.
Majera D, Kristan K, Neefjes J, Turk D, Mihelic M
FEBS Lett
. 2012 Apr;
586(9):1318-24.
PMID: 22465664
Major histocompatibility class (MHC) II molecules are essential for running adaptive immune response. They are produced in the ER and targeted to late endosomes with the help of invariant chain...