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Duncan Sinclair

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Articles 23
Citations 486
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Recent Articles
1.
Farnum Z, Mani R, Bindoff A, Wilson R, Fiotakis A, Stephens J, et al.
J Neurochem . 2024 Nov; 169(2):e16263. PMID: 39556451
Stressful life events and glucocorticoid (stress) hormones appear to increase the risk of Alzheimer's disease and hasten its progression, but the reasons for this remain unclear. One potential explanation is...
2.
Sinclair D, Canty A, Ziebell J, Woodhouse A, Collins J, Perry S, et al.
Alzheimers Dement . 2024 Apr; 20(6):4260-4289. PMID: 38687209
Experimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate...
3.
Tran C, Weickert C, Weickert T, Sinclair D
Int J Mol Sci . 2022 May; 23(10). PMID: 35628144
Early life stress shapes the developing brain and increases risk for psychotic disorders. Yet, it is not fully understood how early life stress impacts brain regions in dopaminergic pathways whose...
4.
Bartlett L, Brady J, Farrow M, Kim S, Bindoff A, Fair H, et al.
Alzheimers Dement (N Y) . 2021 May; 7(1):e12169. PMID: 34027023
Introduction: Containment measures implemented to minimize the spread of coronavirus disease 2019 (COVID-19) are reported to be negatively affecting mental health, diet, and alcohol consumption. These factors, as well as...
5.
Lee C, Sinclair D, ODonnell M, Galletly C, Liu D, Weickert C, et al.
Schizophr Res . 2019 Jul; 213:87-95. PMID: 31296417
Altered levels of stress-signalling transcripts have been identified in post-mortem brains of people with schizophrenia, and since stress effects may be expressed throughout the body, there should be similar changes...
6.
Zieba J, Sinclair D, Sebree T, Bonn-Miller M, Gutterman D, Siegel S, et al.
Pharmacol Biochem Behav . 2019 May; 181:93-100. PMID: 31063743
Fragile X Syndrome is a neurodevelopmental disorder which affects intellectual, social and physical development due to mutation of the Fragile X mental retardation 1 (FMR1) gene. The resultant loss of...
7.
Olaya J, Heusner C, Matsumoto M, Sinclair D, Kondo M, Karl T, et al.
Schizophr Bull . 2017 Oct; 44(4):865-875. PMID: 28981869
Neuregulin 1 (NRG1) is a schizophrenia candidate gene whose protein product is involved in neuronal migration, survival, and synaptic plasticity via production of specific isoforms. Importantly, NRG1 type III (NRG1...
8.
Egbujo C, Sinclair D, Hahn C
Curr Psychiatry Rep . 2016 Jul; 18(8):77. PMID: 27371030
Schizophrenia is a serious psychiatric illness which is experienced by about 1 % of individuals worldwide and has a debilitating impact on perception, cognition, and social function. Over the years,...
9.
Sinclair D, Cesare J, McMullen M, Carlson G, Hahn C, Borgmann-Winter K
J Neurodev Disord . 2016 May; 8:14. PMID: 27134685
Background: Neurodevelopmental disorders such as autism spectrum disorders and schizophrenia differentially impact males and females and are highly heritable. The ways in which sex and genetic vulnerability influence the pathogenesis...
10.
Weickert C, Webster M, Boerrigter D, Sinclair D
Biol Psychiatry . 2016 Jan; 80(5):e29-31. PMID: 26805584
No abstract available.