Duncan Sinclair
Overview
Explore the profile of Duncan Sinclair including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
486
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Recent Articles
11.
Egbujo C, Sinclair D, Borgmann-Winter K, Arnold S, Turetsky B, Hahn C
Schizophr Res
. 2015 Aug;
168(1-2):554-62.
PMID: 26260078
Multiple lines of evidence suggest altered synaptic plasticity/connectivity as a pathophysiologic mechanism for various symptom domains of schizophrenia. Olfactory dysfunction, an endophenotype of schizophrenia, reflects altered activity of the olfactory...
12.
Sinclair D, Purves-Tyson T, Allen K, Weickert C
Psychopharmacology (Berl)
. 2014 Feb;
231(8):1581-99.
PMID: 24481565
Rationale: Adolescence is a developmental period of complex neurobiological change and heightened vulnerability to psychiatric illness. As a result, understanding factors such as sex and stress hormones which drive brain...
13.
Sinclair D, Fillman S, Webster M, Weickert C
Sci Rep
. 2013 Dec;
3:3539.
PMID: 24345775
Molecular abnormalities within the glucocorticoid receptor (GR) stress signaling pathway may confer, or reflect, susceptibility to stress in schizophrenia and bipolar disorder, but the extent of such abnormalities in the...
14.
Catts V, Fung S, Long L, Joshi D, Vercammen A, Allen K, et al.
Front Cell Neurosci
. 2013 May;
7:60.
PMID: 23720610
The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly...
15.
Sinclair D, Webster M, Fullerton J, Weickert C
BMC Psychiatry
. 2012 Jul;
12:84.
PMID: 22812453
Background: The orbitofrontal cortex (OFC) may play a role in the pathogenesis of psychiatric illnesses such as bipolar disorder and schizophrenia, in which hypothalamic-pituitary-adrenal (HPA) axis abnormalities are observed and...
16.
Sinclair D, Fullerton J, Webster M, Weickert C
PLoS One
. 2012 Mar;
7(3):e31720.
PMID: 22427805
Abnormal patterns of HPA axis activation, under basal conditions and in response to stress, are found in individuals with schizophrenia and bipolar disorder. Altered glucocorticoid receptor (GR) mRNA and protein...
17.
Sinclair D, Tsai S, Woon H, Weickert C
Neuropsychopharmacology
. 2011 Sep;
36(13):2698-709.
PMID: 21881570
Stress has been implicated in the onset and illness course of schizophrenia and bipolar disorder. The effects of stress in these disorders may be mediated by abnormalities of the hypothalamic-pituitary-adrenal...
18.
Ellis J, Sinclair D, Morrison D, Al-Qassab S, Springett K, Ivens A
Mol Biochem Parasitol
. 2010 Sep;
174(2):117-27.
PMID: 20817048
Neospora caninum is a coccidian cyst-forming parasite found in a wide range of host species such as mice, dogs and cattle. The development of methods such as vaccines to prevent...
19.
Gordon A, Callaghan D, Spink D, Cloutier C, Dzongowski P, OMahony W, et al.
Clin Ther
. 2010 Aug;
32(5):844-60.
PMID: 20685494
Background: Buprenorphine is a mixed-activity, partial mu-opioid agonist. Its lipid solubility makes it well suited for transdermal administration. Objective: This study assessed the efficacy and safety profile of a 7-day...
20.
Flood C, Sinclair D
Healthc Pap
. 2004 Oct;
5(1):63-8.
PMID: 15496819
In response to what we describe as the "accountability gap" in healthcare, nine provinces have embraced the devolution of management responsibility and authority from central government administrations to regional health...