Dumitrita Iftime
Overview
Explore the profile of Dumitrita Iftime including associated specialties, affiliations and a list of published articles.
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8
Citations
86
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Recent Articles
1.
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, et al.
Nucleic Acids Res
. 2024 Dec;
53(D1):D678-D690.
PMID: 39657789
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is...
2.
Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides
Hansen M, Adamek M, Iftime D, Petras D, Schuseil F, Grond S, et al.
Nat Commun
. 2023 Nov;
14(1):7842.
PMID: 38030603
Antibiotics are central to modern medicine, and yet they are mainly the products of intra and inter-kingdom evolutionary warfare. To understand how nature evolves antibiotics around a common mechanism of...
3.
Ho Y, Schittenhelm R, Iftime D, Stegmann E, Tailhades J, Cryle M
Chembiochem
. 2022 Dec;
24(6):e202200686.
PMID: 36534957
The glycopeptide antibiotics (GPAs) are a clinically approved class of antimicrobial agents that classically function through the inhibition of bacterial cell-wall biosynthesis by sequestration of the precursor lipid II. The...
4.
Greule A, Izore T, Iftime D, Tailhades J, Schoppet M, Zhao Y, et al.
Nat Commun
. 2019 Jun;
10(1):2613.
PMID: 31197182
Kistamicin is a divergent member of the glycopeptide antibiotics, a structurally complex class of important, clinically relevant antibiotics often used as the last resort against resistant bacteria. The extensively crosslinked...
5.
Iftime D, Jasyk M, Kulik A, Imhoff J, Stegmann E, Wohlleben W, et al.
Chembiochem
. 2015 Oct;
16(18):2615-23.
PMID: 26437689
Lanthipeptides are ribosomally synthesized and post-translationally modified microbial secondary metabolites. Here, we report the identification and isolation of streptocollin from Streptomyces collinus Tü 365, a new member of class IV...
6.
Iftime D, Kulik A, Hartner T, Rohrer S, Niedermeyer T, Stegmann E, et al.
J Ind Microbiol Biotechnol
. 2015 Oct;
43(2-3):277-91.
PMID: 26433383
Streptomycetes are prolific sources of novel biologically active secondary metabolites with pharmaceutical potential. S. collinus Tü 365 is a Streptomyces strain, isolated 1972 from Kouroussa (Guinea). It is best known...
7.
Ruckert C, Szczepanowski R, Albersmeier A, Goesmann A, Iftime D, Musiol E, et al.
J Biotechnol
. 2013 Oct;
168(4):739-40.
PMID: 24140291
Streptomyces collinus Tü 365 (DSMZ 40733), isolated from Kouroussa (Guinea), is the producer of the elfamycin family antibiotic kirromycin, which inhibits bacterial protein biosynthesis by interfering with elongation factor EF-Tu....
8.
Iftime D, Hannah M, Peterbauer T, Heyer A
Plant Sci
. 2011 Mar;
180(1):24-30.
PMID: 21421343
We expressed the stachyose synthase from adzuki bean (Vigna angularis) in Arabidopsis thaliana, under the control of the constitutive CaMV 35S promoter. Transgenic lines had only trace amounts of stachyose...