Dror Tobi
Overview
Explore the profile of Dror Tobi including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
555
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0
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Recent Articles
1.
Panja A, Sharma V, Mitra P, Bazylevich A, Drori C, Kayet A, et al.
Bioorg Med Chem
. 2024 Jun;
109:117794.
PMID: 38875875
Dolastatin 10 (Dol-10), a natural marine-source pentapeptide, is a powerful antimitotic agent regarded as one of the most potent anticancer compounds found to date. Dol-10 however, lacks chemical conjugation capabilities,...
2.
Yakovenko I, Tobi D, Ner-Gaon H, Oren M
Front Immunol
. 2023 Feb;
13:1066510.
PMID: 36726993
The closely linked recombination activating genes ( and ) in vertebrates encode the core of the RAG recombinase that mediates the V(D)J recombination of the immunoglobulin and T-cell receptor genes....
3.
Furman O, Zaporozhets A, Tobi D, Bazylevich A, Firer M, Patsenker L, et al.
Pharmaceutics
. 2022 Jul;
14(7).
PMID: 35890400
The epidermal growth factor-epidermal growth factor receptor (EGF-EGFR) pathway has become the main focus of selective chemotherapeutic intervention. As a result, two classes of EGFR inhibitors have been clinically approved,...
4.
Tobi D, Krashin E, Davis P, Cody V, Ellis M, Ashur-Fabian O
Front Endocrinol (Lausanne)
. 2022 Jun;
13:895240.
PMID: 35692387
Background: Thyroid hormones (TH), T4 and T3, mediate pro-mitogenic effects in cancer cells through binding the membrane receptor αvβ3 integrin. The deaminated analogue tetrac effectively blocks TH binding to this...
5.
Pernicone N, Elias M, Onn I, Tobi D, Listovsky T
Molecules
. 2022 Feb;
27(3).
PMID: 35163901
DNA-damaging chemotherapy agents such as cisplatin have been the first line of treatment for cancer for decades. While chemotherapy can be very effective, its long-term success is often reduced by...
6.
Bern D, Tobi D
Proteins
. 2022 Jan;
90(6):1267-1277.
PMID: 35084062
The Kaposi's sarcoma-associated herpesvirus protease is essential for virus maturation. This protease functions under allosteric regulation that establishes its enzymatic activity upon dimerization. It exists in equilibrium between an inactive...
7.
Aharoni R, Tobi D
PLoS One
. 2019 Dec;
14(12):e0226147.
PMID: 31821368
Drosha and Dicer are RNase III family members of classes II and III, respectively, which play a major role in the maturation of micro-RNAs. The two proteins share similar domain...
8.
Tobi D
PLoS One
. 2018 Dec;
13(12):e0208465.
PMID: 30513111
A methodology to cluster proteins based on their dynamics' similarity is presented. For each pair of proteins from a dataset, the structures are superimposed, and the Anisotropic Network Model modes...
9.
Aharoni R, Tobi D
Proteins
. 2018 Sep;
86(11):1176-1183.
PMID: 30183107
Myoglobin and hemoglobin are globular hemeproteins, when the former is a monomer and the latter a heterotetramer. Despite the structural similarity of myoglobin to α and β subunits of hemoglobin,...
10.
Tobi D
Proteins
. 2017 May;
85(8):1507-1517.
PMID: 28459140
A new algorithm for comparison of protein dynamics is presented. Compared protein structures are superposed and their modes of motions are calculated using the anisotropic network model. The obtained modes...