Douglas Vollrath
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Explore the profile of Douglas Vollrath including associated specialties, affiliations and a list of published articles.
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59
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2301
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Recent Articles
1.
Chen M, Wang Y, Dalal R, Du J, Vollrath D
Proc Natl Acad Sci U S A
. 2024 Jun;
121(25):e2402384121.
PMID: 38865272
Loss of mitochondrial electron transport complex (ETC) function in the retinal pigment epithelium (RPE) in vivo results in RPE dedifferentiation and progressive photoreceptor degeneration, and has been implicated in the...
2.
Ghosh S, Finnemann S, Vollrath D, Rothlin C
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791338
Greg Lemke's laboratory was one of the pioneers of research into the TAM family of receptor tyrosine kinases (RTKs). Not only was cloned in his laboratory, but his group also...
3.
Ding J, Lee S, Vlahos L, Yuki K, Rada C, van Unen V, et al.
Nat Commun
. 2023 Jun;
14(1):2947.
PMID: 37268690
Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The Norrin/FZD/TSPAN12 pathway activates WNT/β-catenin signaling, which is...
4.
Ning K, Bhuckory M, Lo C, Sendayen B, Kowal T, Chen M, et al.
Sci Rep
. 2023 May;
13(1):8205.
PMID: 37211572
Primary cilia are conserved organelles that integrate extracellular cues into intracellular signals and are critical for diverse processes, including cellular development and repair responses. Deficits in ciliary function cause multisystemic...
5.
Chen M, Kim L, Lu C, Zeng H, Vollrath D
Exp Eye Res
. 2020 Dec;
202:108370.
PMID: 33264655
Cre-mediated modulation of gene function in the murine retinal pigment epithelium (RPE) has been widely used, but current postnatal RPE-selective Cre driver lines suffer from limited recombination efficiency and/or ectopic...
6.
Moore T, Yanes R, Calton M, Vollrath D, Enns G, Cowan T
PLoS One
. 2020 Oct;
15(10):e0240517.
PMID: 33052980
Mitochondrial diseases are a clinically heterogenous group of disorders caused by respiratory chain dysfunction and associated with progressive, multi-systemic phenotype. There is no effective treatment or cure, and no FDA-approved...
7.
Hu X, Calton M, Tang S, Vollrath D
Sci Rep
. 2019 Oct;
9(1):15355.
PMID: 31653972
We investigated the effects of treating differentiated retinal pigment epithelial (RPE) cells with didanosine (ddI), which is associated with retinopathy in individuals with HIV/AIDS. We hypothesized that such treatment would...
8.
Fan B, Cooke Bailey J, Igo Jr R, Kang J, Boumenna T, Brilliant M, et al.
JAMA Ophthalmol
. 2019 Aug;
137(10):1190-1194.
PMID: 31436842
Importance: Genetic variants associated with primary open-angle glaucoma (POAG) are known to influence disease risk. However, the clinical effect of associated variants individually or in aggregate is not known. Genetic...
9.
Zhang Q, Presswalla F, Calton M, Charniga C, Stern J, Temple S, et al.
Invest Ophthalmol Vis Sci
. 2019 Aug;
60(10):3468-3479.
PMID: 31408109
Purpose: The accumulation of undigestible autofluorescent material (UAM), termed lipofuscin in vivo, is a hallmark of aged RPE. Lipofuscin derives, in part, from the incomplete degradation of phagocytized photoreceptor outer...
10.
Liu B, Calton M, Abell N, Benchorin G, Gloudemans M, Chen M, et al.
Commun Biol
. 2019 May;
2:186.
PMID: 31123710
The retinal pigment epithelium (RPE) serves vital roles in ocular development and retinal homeostasis but has limited representation in large-scale functional genomics datasets. Understanding how common human genetic variants affect...