Douglas S Darling
Overview
Explore the profile of Douglas S Darling including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
1563
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0
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Recent Articles
1.
Sanchez-Tillo E, Pedrosa L, Vila I, Chen Y, Gyorffy B, Sanchez-Moral L, et al.
JCI Insight
. 2023 Oct;
8(20.
PMID: 37870961
Despite being in the same pathway, mutations of KRAS and BRAF in colorectal carcinomas (CRCs) determine distinct progression courses. ZEB1 induces an epithelial-to-mesenchymal transition (EMT) and is associated with worse...
2.
Vandamme N, Denecker G, Bruneel K, Blancke G, Akay O, Taminau J, et al.
Cancer Res
. 2020 Jun;
80(14):2983-2995.
PMID: 32503808
Epithelial-to-mesenchymal transition (EMT)-inducing transcription factors (TF) are well known for their ability to induce mesenchymal states associated with increased migratory and invasive properties. Unexpectedly, nuclear expression of the EMT-TF ZEB2...
3.
de Barrios O, Sanchez-Moral L, Cortes M, Ninfali C, Profitos-Peleja N, Martinez-Campanario M, et al.
Gut
. 2019 Aug;
68(12):2129-2141.
PMID: 31366457
Objective: Chronic inflammation is a risk factor in colorectal cancer (CRC) and reactive oxygen species (ROS) released by the inflamed stroma elicit DNA damage in epithelial cells. We sought to...
4.
Siles L, Ninfali C, Cortes M, Darling D, Postigo A
Nat Commun
. 2019 Mar;
10(1):1364.
PMID: 30910999
The mechanisms linking muscle injury and regeneration are not fully understood. Here we report an unexpected role for ZEB1 regulating inflammatory and repair responses in dystrophic and acutely injured muscles....
5.
Ninfali C, Siles L, Darling D, Postigo A
Nucleic Acids Res
. 2018 Oct;
46(20):10697-10708.
PMID: 30304480
Multiple physiopathological and clinical conditions trigger skeletal muscle atrophy through the induction of a group of proteins (atrogenes) that includes components of the ubiquitin-proteasome and autophagy-lysosomal systems. Atrogenes are induced...
6.
Natsuizaka M, Whelan K, Kagawa S, Tanaka K, Giroux V, Chandramouleeswaran P, et al.
Nat Commun
. 2017 Nov;
8(1):1758.
PMID: 29170450
Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (SCCs). However,...
7.
Cortes M, Sanchez-Moral L, de Barrios O, Fernandez-Acenero M, Martinez-Campanario M, Esteve-Codina A, et al.
EMBO J
. 2017 Oct;
36(22):3336-3355.
PMID: 29038174
Accumulation of tumor-associated macrophages (TAMs) associates with malignant progression in cancer. However, the mechanisms that drive the pro-tumor functions of TAMs are not fully understood. ZEB1 is best known for...
8.
Chen Y, Lu X, Montoya-Durango D, Liu Y, Dean K, Darling D, et al.
Sci Rep
. 2017 Mar;
7(1):45.
PMID: 28246385
Human uveal melanoma (UM) is a major ocular malignant tumor with high risk of metastasis and requires multiple oncogenic factors for progression. ZEB1 is a zinc finger E-box binding transcription...
9.
de Barrios O, Gyorffy B, Fernandez-Acenero M, Sanchez-Tillo E, Sanchez-Moral L, Siles L, et al.
Gut
. 2016 Dec;
66(4):666-682.
PMID: 27965283
Objective: Understand the role of ZEB1 in the tumour initiation and progression beyond inducing an epithelial-to-mesenchymal transition. Design: Expression of the transcription factor ZEB1 associates with a worse prognosis in...
10.
Ohayon D, Garces A, Joly W, Soukkarieh C, Takagi T, Sabourin J, et al.
Cell Rep
. 2016 Nov;
17(6):1473-1481.
PMID: 27806288
During spinal cord development, astrocyte precursors arise from neuroepithelial progenitors, delaminate from the ventricular zone, and migrate toward their final locations where they differentiate. Although the mechanisms underlying their early...