Douglas J Tobias
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Explore the profile of Douglas J Tobias including associated specialties, affiliations and a list of published articles.
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139
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3936
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Recent Articles
11.
Diessner E, Freites J, Tobias D, Butts C
J Phys Chem B
. 2023 Jan;
127(3):685-697.
PMID: 36637342
Network Hamiltonian models (NHMs) are a framework for topological coarse-graining of protein-protein interactions, in which each node corresponds to a protein, and edges are drawn between nodes representing proteins that...
12.
Fan H, Frank E, Tobias D, Grassian V
Phys Chem Chem Phys
. 2022 Sep;
24(38):23870-23883.
PMID: 36165087
Limonene, a monoterpene, found in cleaning products and air fresheners can interact with a variety of surfaces in indoor environments. An oxidation product of limonene, carvone, has been reported to...
13.
Vasquez-Montes V, Tyagi V, Sikorski E, Kyrychenko A, Freites J, Thevenin D, et al.
Protein Sci
. 2022 Aug;
31(9):e4385.
PMID: 36040255
Cancerous tissues undergo extensive changes to their cellular environments that differentiate them from healthy tissues. These changes include changes in extracellular pH and Ca concentrations, and the exposure of phosphatidylserine...
14.
Zhou Z, Lakey P, von Domaros M, Wise N, Tobias D, Shiraiwa M, et al.
Environ Sci Technol
. 2022 Jun;
56(12):7716-7728.
PMID: 35671499
Commonly found in atmospheric aerosols, cooking oils, and human sebum, unsaturated lipids rapidly decay upon exposure to ozone, following the Criegee mechanism. Here, the gas-surface ozonolysis of three oleic acid-based...
15.
Tyagi V, Vasquez-Montes V, Freites J, Kyrychenko A, Tobias D, Ladokhin A
Int J Mol Sci
. 2021 Sep;
22(17).
PMID: 34502299
The anti-apoptotic protein Bcl-xL regulates apoptosis by preventing the permeation of the mitochondrial outer membrane by pro-apoptotic pore-forming proteins, which release apoptotic factors into the cytosol that ultimately lead to...
16.
Geragotelis A, Freites J, Tobias D
J Phys Chem B
. 2021 Aug;
125(35):9990-9998.
PMID: 34459592
Peripheral membrane proteins bind transiently to membrane surfaces as part of many signaling pathways. The bound proteins perform two-dimensional (2-D) diffusion on the membrane surface during the recruitment function. To...
17.
Zhao C, Hong L, Riahi S, Lim V, Tobias D, Tombola F
J Gen Physiol
. 2021 Jul;
153(9).
PMID: 34228045
Voltage-gated sodium, potassium, and calcium channels consist of four voltage-sensing domains (VSDs) that surround a central pore domain and transition from a down state to an up state in response...
18.
Zhao C, Hong L, Galpin J, Riahi S, Lim V, Webster P, et al.
J Gen Physiol
. 2021 Jul;
153(9).
PMID: 34228044
The human voltage-gated proton channel Hv1 is a drug target for cancer, ischemic stroke, and neuroinflammation. It resides on the plasma membrane and endocytic compartments of a variety of cell...
19.
Huang L, Frank E, Shrestha M, Riahi S, Tobias D, Grassian V
Environ Sci Technol
. 2021 May;
55(10):6623-6630.
PMID: 33945687
Oxygenated organic compounds (OOCs) are widely found in indoor environments and come from either the direct emissions from indoor activities or the subsequent oxidation of nonoxygenated OCs. Adsorption and partitioning...
20.
von Domaros M, Liu Y, Butman J, Perlt E, Geiger F, Tobias D
J Phys Chem B
. 2021 Apr;
125(15):3932-3941.
PMID: 33835820
Human skin oils are significant scavengers of atmospheric oxidants in occupied indoor environments, and squalene is a major ozone-active constituent. Here, we present a combined spectroscopic and atomistic modeling approach...