Douglas J Tobias
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Explore the profile of Douglas J Tobias including associated specialties, affiliations and a list of published articles.
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139
Citations
3936
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Recent Articles
1.
Song Y, Li Z, Mulvey J, Freites J, Patterson J, Tobias D
Chemphyschem
. 2025 Mar;
:e202401085.
PMID: 40032615
Disulfide hydrogels, derived from cysteine-based redox systems, exhibit active self-assembly properties driven by reversible disulfide bond formation, making them a versatile platform for dynamic material design. Detailed cryogenic electron microscopy...
2.
Thomas R, Prabhakar P, Tobias D, von Domaros M
J Phys Chem B
. 2025 Feb;
129(6):1784-1794.
PMID: 39901666
The oxidation of human sebum, a lipid mixture covering our skin, generates a range of volatile and semivolatile carbonyl compounds that contribute largely to indoor air pollution in crowded environments....
3.
von Domaros M, Tobias D
Annu Rev Phys Chem
. 2025 Feb;
PMID: 39899840
With markedly different reaction conditions compared to the chemistry of the outside atmosphere, indoor air chemistry poses new challenges to the scientific community that require combined experimental and computational efforts....
4.
Ly A, Freites J, Bertaccini G, Evans E, Dickinson G, Tobias D, et al.
Biophys J
. 2025 Jan;
PMID: 39844465
The mechanically activated ion channel PIEZO1 is critical to numerous physiological processes, and is activated by diverse mechanical cues. The channel is gated by membrane tension and has been found...
5.
Liu Y, Li C, Freites J, Tobias D, Voth G
Proc Natl Acad Sci U S A
. 2024 Sep;
121(38):e2407479121.
PMID: 39259593
Human voltage-gated proton (hHv1) channels are crucial for regulating essential biological processes such as immune cell respiratory burst, sperm capacitation, and cancer cell migration. Despite the significant concentration difference between...
6.
Freites J, Tobias D
J Phys Chem B
. 2024 Jul;
128(31):7577-7585.
PMID: 39052430
Aquaporin 0 (AQP0) plays a key role in water circulation in the eye lens through a variety of functions. In contrast to mammalian genomes, zebrafish contains two genes leading to...
7.
Song Y, Selmani S, Freites J, Guan Z, Tobias D
J Phys Chem B
. 2024 Jan;
128(5):1266-1274.
PMID: 38290526
Inspired by the adaptability observed in biological materials, self-assembly processes have attracted significant interest for their potential to yield novel materials with unique properties. However, experimental methods have often fallen...
8.
Manville R, Freites J, Sidlow R, Tobias D, Abbott G
Nat Commun
. 2023 Jun;
14(1):3281.
PMID: 37280215
There are currently no drugs known to rescue the function of Kv1.1 voltage-gated potassium channels carrying loss-of-function sequence variants underlying the inherited movement disorder, Episodic Ataxia 1 (EA1). The Kwakwaka'wakw...
9.
Freites J, Louis M, Tobias D
J Comput Chem
. 2023 Apr;
44(19):1658-1666.
PMID: 37093714
The molecular basis underlying the rich phase behavior of globular proteins remains poorly understood. We use atomistic multiscale molecular simulations to model the solution-state conformational dynamics and interprotein interactions of...
10.
Frank E, Fan H, Grassian V, Tobias D
Phys Chem Chem Phys
. 2023 Jan;
25(5):3930-3941.
PMID: 36648281
The compound 6-methyl-5-hepten-2-one (6-MHO) is a product of skin oil ozonolysis and is of significance in understanding the role of human occupants in the indoor environment. We present a joint...