Douglas G Osborne
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Explore the profile of Douglas G Osborne including associated specialties, affiliations and a list of published articles.
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16
Citations
531
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Recent Articles
1.
Johnson J, Meneses-Salas E, Ramadass M, Monfregola J, Rahman F, Carvalho Gontijo R, et al.
Nat Commun
. 2022 Sep;
13(1):5529.
PMID: 36130971
Dysregulated secretion in neutrophil leukocytes associates with human inflammatory disease. The exocytosis response to triggering stimuli is sequential; gelatinase granules modulate the initiation of the innate immune response, followed by...
2.
Knitz M, Bickett T, Darragh L, Oweida A, Bhatia S, Van Court B, et al.
J Immunother Cancer
. 2021 Apr;
9(4).
PMID: 33883256
Background: Numerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint...
3.
Tengesdal I, Menon D, Osborne D, Neff C, Powers N, Gamboni F, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(10).
PMID: 33649199
Interleukin-1β (IL-1β)-mediated inflammation suppresses antitumor immunity, leading to the generation of a tumor-permissive environment, tumor growth, and progression. Here, we demonstrate that nucleotide-binding domain, leucine-rich containing family, pyrin domain-containing-3 (NLRP3)...
4.
Walpole G, Plumb J, Chung D, Tang B, Boulay B, Osborne D, et al.
Cell Rep
. 2020 Jun;
31(9):107721.
PMID: 32492429
Burkholderia cenocepacia is an opportunistic bacterial pathogen that causes severe pulmonary infections in cystic fibrosis and chronic granulomatous disease patients. B. cenocepacia can survive inside infected macrophages within the B. ...
5.
Luckey D, Weaver E, Osborne D, Billadeau D, Taneja V
Sci Rep
. 2019 Dec;
9(1):19061.
PMID: 31836763
Major histocompatibility complex II (MHC II) molecules are involved in antigen presentation and the development of a functional adaptive immune response. Evolutionary selection for MHC molecules that effectively clear infectious...
6.
Osborne D, Domenico J, Luo Y, Reid A, Amato C, Zhai Z, et al.
Mol Carcinog
. 2019 May;
58(9):1670-1679.
PMID: 31099111
Immune suppression is one of the 10 hallmarks of cancer. Interleukin-37 (IL-37), a member of the IL-1 family, inhibits both innate and adaptive immunity, and has been shown to modulate...
7.
Ravindran Menon D, Luo Y, Arcaroli J, Liu S, KrishnanKutty L, Osborne D, et al.
Cancer Res
. 2018 Oct;
78(23):6561-6574.
PMID: 30297536
: Cancers are composed of heterogeneous subpopulations with various tumor-initiating capacities, yet key stem cell genes associated with enhanced tumor-initiating capacities and their regulatory mechanisms remain elusive. Here, we analyzed...
8.
Kremer K, Dinkel B, Sterner R, Osborne D, Jevremovic D, Hedin K
Blood
. 2017 Jul;
130(8):982-994.
PMID: 28694325
As with many immunopathologically driven diseases, the malignant T cells of cutaneous T-cell lymphomas (CTCLs), such as Sézary syndrome, display aberrant cytokine secretion patterns that contribute to pathology and disease...
9.
Jia D, Zhang J, Li F, Wang J, Deng Z, White M, et al.
Nat Commun
. 2016 Nov;
7:13305.
PMID: 27827364
Retromer is a membrane coat complex that is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. The timing of this interaction and consequent endosomal dynamics are...
10.
Osborne D, Phillips-Krawczak C, Billadeau D
Methods Cell Biol
. 2015 Sep;
130:199-213.
PMID: 26360036
Cell surface receptors that have been internalized and enter the endocytic pathway have multiple fates including entrance into the multivesicular body pathway on their way to lysosomal degradation, recycling back...