Douglas C Bittel
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Explore the profile of Douglas C Bittel including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
1008
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Recent Articles
1.
Trevino C, Holleman A, Corbitt H, Maslen C, Rosser T, Cutler D, et al.
Sci Rep
. 2021 Jul;
11(1):15164.
PMID: 34285246
No abstract available.
2.
Trevino C, Holleman A, Corbitt H, Maslen C, Rosser T, Cutler D, et al.
Sci Rep
. 2020 Oct;
10(1):18051.
PMID: 33093519
Atrioventricular septal defects (AVSD) are a severe congenital heart defect present in individuals with Down syndrome (DS) at a > 2000-fold increased prevalence compared to the general population. This study...
3.
Nagasawa C, Kibiryeva N, Marshall J, OBrien Jr J, Bittel D
Pediatr Cardiol
. 2020 Jan;
41(2):341-349.
PMID: 31953571
The heart is the first major organ to develop during embryogenesis and must receive proper spatiotemporal signaling for proper development. Failure of proper signaling between the first and second heart...
4.
Ogren A, Kibiryeva N, Marshall J, OBrien Jr J, Bittel D
PLoS One
. 2019 Dec;
14(12):e0226035.
PMID: 31805133
Understanding the regulation of development can help elucidate the pathogenesis behind many developmental defects found in humans and other vertebrates. Evidence has shown that alternative splicing of messenger RNA (mRNA)...
5.
Nagasawa C, Ogren A, Kibiryeva N, Marshall J, OBrien J, Kenmochi N, et al.
J Cardiovasc Dev Dis
. 2018 May;
5(2).
PMID: 29738469
Congenital heart disease (CHD) is a leading cause of death in children <1 year of age. Despite intense effort in the last 10 years, most CHDs (~70%) still have an...
6.
Cao T, Rajasingh S, Samanta S, Dawn B, Bittel D, Rajasingh J
Trends Cardiovasc Med
. 2017 Sep;
28(2):81-90.
PMID: 28869095
Small nucleolar RNAs (snoRNAs) are a group of noncoding RNAs that perform various biological functions, including biochemical modifications of other RNAs, precursors of miRNA, splicing, and telomerase activity. The small...
7.
Bittel D, Kibiryeva N, OBrien J, Lofland G, Butler M
Prog Pediatr Cardiol
. 2017 May;
20(2):127-141.
PMID: 28529438
Developmental abnormalities of the heart are the underlying cause of many congenital heart malformations. The embryological development of the integrated cardiovascular tissue is the result of multiple tissue and cell-to-cell...
8.
Riordan S, Bittel D, Le Pichon J, Gazzin S, Tiribelli C, Watchko J, et al.
Front Neurosci
. 2016 Sep;
10:376.
PMID: 27587993
Genetic-based susceptibility to bilirubin neurotoxicity and chronic bilirubin encephalopathy (kernicterus) is still poorly understood. Neonatal jaundice affects 60-80% of newborns, and considerable effort goes into preventing this relatively benign condition...
9.
Patil P, Kibiryeva N, Uechi T, Marshall J, OBrien Jr J, Artman M, et al.
Biochim Biophys Acta
. 2015 Apr;
1852(8):1619-29.
PMID: 25916634
Alternative splicing (AS) plays an important role in regulating mammalian heart development, but a link between misregulated splicing and congenital heart defects (CHDs) has not been shown. We reported that...
10.
Stanford J, Shuler J, Fowler S, Stanford K, Ma D, Bittel D, et al.
Pediatr Res
. 2014 Dec;
77(3):434-9.
PMID: 25518009
Background: Neonatal jaundice resulting from elevated unconjugated bilirubin occurs in 60-80% of newborn infants. Although mild jaundice is generally considered harmless, little is known about its long-term consequences. Recent studies...