Doug Horsman
Overview
Explore the profile of Doug Horsman including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
6118
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Recent Articles
1.
Nagel I, Szczepanowski M, Martin-Subero J, Harder L, Akasaka T, Ammerpohl O, et al.
Blood
. 2010 May;
116(8):1317-20.
PMID: 20460502
Sequence variants at the TERT-CLPTM1L locus in chromosome 5p have been recently associated with disposition for various cancers. Here we show that this locus including the gene encoding the telomerase...
2.
Metcalfe K, Ghadirian P, Rosen B, Foulkes W, Kim-Sing C, Eisen A, et al.
Open Med
. 2010 Jan;
1(2):e92-8.
PMID: 20101300
Background: Women with a BRCA1 or BRCA2 genetic mutation have several options for cancer prevention, including prophylactic surgery, chemoprevention and screening. In this study we report on preventive practices used...
3.
Krzywinski M, Schein J, Birol I, Connors J, Gascoyne R, Horsman D, et al.
Genome Res
. 2009 Jun;
19(9):1639-45.
PMID: 19541911
We created a visualization tool called Circos to facilitate the identification and analysis of similarities and differences arising from comparisons of genomes. Our tool is effective in displaying variation in...
4.
Maisonneuve A, Huiart L, Rabayrol L, Horsman D, Didelot R, Sobol H, et al.
Int J Med Sci
. 2008 Sep;
5(5):244-7.
PMID: 18769562
Background: Chemoprevention could significantly reduce cancer burden. Assessment of efficacy and risk/benefit balance is at best achieved through randomized clinical trials. Methods: At a periodic health examination center 1463 adults...
5.
Salaverria I, Bea S, Lopez-Guillermo A, Lespinet V, Pinyol M, Burkhardt B, et al.
Br J Haematol
. 2008 Feb;
140(5):516-26.
PMID: 18275429
Anaplastic large cell lymphoma (ALCL) is a T/null-cell neoplasm characterized by chromosomal translocations involving the anaplastic lymphoma kinase (ALK) gene (ALK). Tumours with similar morphology and phenotype but negative for...
6.
Press J, De Luca A, Boyd N, Young S, Troussard A, Ridge Y, et al.
BMC Cancer
. 2008 Jan;
8:17.
PMID: 18208621
Background: Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethylation can...
7.
Pugh T, Bebb G, Barclay L, Sutcliffe M, Fee J, Salski C, et al.
BMC Cancer
. 2007 Jul;
7:128.
PMID: 17626639
Background: Gefitinib, a small molecule tyrosine kinase inhibitor of the Epidermal Growth Factor Receptor (EGFR), has shown limited efficacy in the treatment of lung cancer. Recognized clinical predictors of response...
8.
Eisinger F, Horsman D
Med Hypotheses
. 2007 Mar;
69(3):690-2.
PMID: 17363177
For many opinion leaders "The genetic revolution in medicine is under way" and this "revolution" is often characterized as occurring within a time frame of a few years. We challenged...
9.
Horsman D, Wilson B, Avard D, Meschino W, Sing C, Plante M, et al.
J Obstet Gynaecol Can
. 2007 Mar;
29(1):45-60.
PMID: 17346477
Background: In Canada, there are wide variations in services for patients at risk for hereditary breast and ovarian cancer (HBOC), and clinical interventions and recommendations differ between regions and/or provinces....
10.
Eisinger F, Tarpin C, Huiart L, Horsman D, Rabayrol L, Didelot R, et al.
Fam Cancer
. 2005 Dec;
4(4):307-11.
PMID: 16341808
Background: Misunderstanding of cancer screening recommendations or messages and confidence in the predictive value of positive familial history of disease may converge to stimulate an over-utilization of screening tests in...