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Doss W Neal

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Articles 43
Citations 674
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Recent Articles
1.
Gregory J, Kraft G, Scott M, Neal D, Farmer B, Smith M, et al.
Diabetes Obes Metab . 2019 Jun; 21(10):2294-2304. PMID: 31183936
Aims: We previously quantified the hypoglycaemia-sparing effect of portal vs peripheral human insulin delivery. The current investigation aimed to determine whether a bioequivalent peripheral vein infusion of a hepatopreferential insulin...
2.
Gregory J, Kraft G, Scott M, Neal D, Farmer B, Smith M, et al.
Diabetes . 2015 Jun; 64(10):3439-51. PMID: 26085570
Hypoglycemia limits optimal glycemic control in type 1 diabetes mellitus (T1DM), making novel strategies to mitigate it desirable. We hypothesized that portal (Po) vein insulin delivery would lessen hypoglycemia. In...
3.
Coate K, Kraft G, Shiota M, Smith M, Farmer B, Neal D, et al.
Am J Physiol Endocrinol Metab . 2015 Mar; 308(10):E860-7. PMID: 25783892
Dogs consuming a hypercaloric high-fat and -fructose diet (52 and 17% of total energy, respectively) or a diet high in either fructose or fat for 4 wk exhibited blunted net...
4.
Coate K, Kraft G, Moore M, Smith M, Ramnanan C, Irimia J, et al.
Am J Physiol Endocrinol Metab . 2014 May; 307(2):E151-60. PMID: 24865981
In dogs consuming a high-fat and -fructose diet (52 and 17% of total energy, respectively) for 4 wk, hepatic glucose uptake (HGU) in response to hyperinsulinemia, hyperglycemia, and portal glucose...
5.
Coate K, Kraft G, Irimia J, Smith M, Farmer B, Neal D, et al.
Diabetes . 2012 Oct; 62(2):392-400. PMID: 23028137
The cellular events mediating the pleiotropic actions of portal vein glucose (PoG) delivery on hepatic glucose disposition have not been clearly defined. Likewise, the molecular defects associated with postprandial hyperglycemia...
6.
Coate K, Kraft G, Lautz M, Smith M, Neal D, Cherrington A
J Nutr . 2011 Jul; 141(9):1643-51. PMID: 21775526
The aim of this study was to elucidate the impact of a high-fat, high-fructose diet (HFFD; fat, 52%; fructose, 17%), in the presence of a partial (~65%) pancreatectomy (PPx), on...
7.
Winnick J, An Z, Ramnanan C, Smith M, Irimia J, Neal D, et al.
Diabetes . 2011 Jan; 60(2):398-407. PMID: 21270252
Objective: The objective of this study was to determine how increasing the hepatic glycogen content would affect the liver's ability to take up and metabolize glucose. Research Design And Methods:...
8.
Coate K, Scott M, Farmer B, Moore M, Smith M, Roop J, et al.
Am J Physiol Endocrinol Metab . 2010 Sep; 299(6):E887-98. PMID: 20823448
The objective of this study was to assess the response of a large animal model to high dietary fat and fructose (HFFD). Three different metabolic assessments were performed during 13...
9.
Ramnanan C, Edgerton D, Rivera N, Irimia-Dominguez J, Farmer B, Neal D, et al.
Diabetes . 2010 Feb; 59(6):1302-11. PMID: 20185816
Objective: Insulin-mediated suppression of hepatic glucose production (HGP) is associated with sensitive intracellular signaling and molecular inhibition of gluconeogenic (GNG) enzyme mRNA expression. We determined, for the first time, the...
10.
Edgerton D, Ramnanan C, Grueter C, Johnson K, Lautz M, Neal D, et al.
Diabetes . 2009 Sep; 58(12):2766-75. PMID: 19755527
Objective: Insulin represses the expression of gluconeogenic genes at the mRNA level, but the hormone appears to have only weak inhibitory effects in vivo. The aims of this study were...