Dorit Trudler
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Explore the profile of Dorit Trudler including associated specialties, affiliations and a list of published articles.
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26
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949
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Recent Articles
1.
Trudler D, Ghatak S, Bula M, Parker J, Talantova M, Luevanos M, et al.
Mol Psychiatry
. 2024 Sep;
PMID: 39349966
MEF2C is a critical transcription factor in neurodevelopment, whose loss-of-function mutation in humans results in MEF2C haploinsufficiency syndrome (MHS), a severe form of autism spectrum disorder (ASD)/intellectual disability (ID). Despite...
2.
Farfara D, Sooliman M, Avrahami L, Royal T, Amram S, Rozenstein-Tsalkovich L, et al.
J Neuroinflammation
. 2023 Jul;
20(1):174.
PMID: 37496076
Background: Alzheimer's disease (AD) is the leading cause of dementia in the world. The pathology of AD is affiliated with the elevation of both tau (τ) and β-amyloid (Aβ) pathologies....
3.
Yang H, Oh C, Amal H, Wishnok J, Lewis S, Schahrer E, et al.
Sci Adv
. 2022 Dec;
8(50):eade0764.
PMID: 36516243
Protein S-nitros(yl)ation (SNO) is a posttranslational modification involved in diverse processes in health and disease and can contribute to synaptic damage in Alzheimer's disease (AD). To identify SNO proteins in...
4.
Oh C, Nakamura T, Beutler N, Zhang X, Pina-Crespo J, Talantova M, et al.
Nat Chem Biol
. 2022 Sep;
19(3):275-283.
PMID: 36175661
Prevention of infection and propagation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a high priority in the Coronavirus Disease 2019 (COVID-19) pandemic. Here we describe S-nitrosylation of multiple...
5.
Oh C, Nakamura T, Beutler N, Zhang X, Pina-Crespo J, Talantova M, et al.
bioRxiv
. 2022 Apr;
PMID: 35411336
Prevention of infection and propagation of SARS-CoV-2 is of high priority in the COVID-19 pandemic. Here, we describe S-nitrosylation of multiple proteins involved in SARS-CoV-2 infection, including angiotensin converting enzyme...
6.
Satoh T, Trudler D, Oh C, Lipton S
Antioxidants (Basel)
. 2022 Jan;
11(1).
PMID: 35052628
Rosemary ( [family Lamiaceae]), an herb of economic and gustatory repute, is employed in traditional medicines in many countries. Rosemary contains carnosic acid (CA) and carnosol (CS), abietane-type phenolic diterpenes,...
7.
Trudler D, Ghatak S, Lipton S
Int J Mol Sci
. 2021 Aug;
22(15).
PMID: 34360966
Neurodegenerative diseases affect millions of people worldwide and are characterized by the chronic and progressive deterioration of neural function. Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic...
8.
Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother T, Tourtellotte W, et al.
Immunity
. 2021 Jun;
54(7):1463-1477.e11.
PMID: 34115964
Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced by metformin rather than other anti-diabetic medications. Detecting of...
9.
Trudler D, Nazor K, Eisele Y, Grabauskas T, Dolatabadi N, Parker J, et al.
Proc Natl Acad Sci U S A
. 2021 Apr;
118(15).
PMID: 33833060
Parkinson's disease is characterized by accumulation of α-synuclein (αSyn). Release of oligomeric/fibrillar αSyn from damaged neurons may potentiate neuronal death in part via microglial activation. Heretofore, it remained unknown if...
10.
Trudler D, Sanz-Blasco S, Eisele Y, Ghatak S, Bodhinathan K, Akhtar M, et al.
J Neurosci
. 2021 Jan;
41(10):2264-2273.
PMID: 33483428
Synaptic and neuronal loss are major neuropathological characteristics of Parkinson's disease. Misfolded protein aggregates in the form of Lewy bodies, comprised mainly of α-synuclein (αSyn), are associated with disease progression,...