Dorien Ward-van Oostwaard
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Explore the profile of Dorien Ward-van Oostwaard including associated specialties, affiliations and a list of published articles.
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31
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2514
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Recent Articles
1.
Gabbin B, Meraviglia V, Angenent M, Ward-van Oostwaard D, Sol W, Mummery C, et al.
Mater Today Bio
. 2023 Oct;
23:100818.
PMID: 37810749
Heart and kidney communicate with one another in an interdependent relationship and they influence each other's behavior reciprocally, as pathological changes in one organ can damage the other. Although independent...
2.
Campostrini G, Kosmidis G, Ward-van Oostwaard D, Davis R, Yiangou L, Ottaviani D, et al.
Cardiovasc Res
. 2022 Apr;
119(1):167-182.
PMID: 35394010
Aims: Human-induced pluripotent stem cell-cardiomyocytes (hiPSC-CMs) are widely used to study arrhythmia-associated mutations in ion channels. Among these, the cardiac sodium channel SCN5A undergoes foetal-to-adult isoform switching around birth. Conventional...
3.
Giacomelli E, Sala L, Ward-van Oostwaard D, Bellin M
Biochem Biophys Res Commun
. 2021 Aug;
572:118-124.
PMID: 34364290
Background: Human induced pluripotent stem cells (hiPSCs) and their derivative cardiomyocytes (hiPSC-CMs) have been successfully used to study the electrical phenotype of cardiac ion channel diseases. However, strategies to mature...
4.
Veldhoven J, Campostrini G, van Gessel C, Ward-van Oostwaard D, Liu R, Mummery C, et al.
Eur J Med Chem
. 2020 Dec;
212:113033.
PMID: 33261899
We synthesized and evaluated three novel series of substituted benzophenones for their allosteric modulation of the human K11.1 (hERG) channel. We compared their effects with reference compound LUF7346 previously shown...
5.
Sala L, Ward-van Oostwaard D, Tertoolen L, Mummery C, Bellin M
J Vis Exp
. 2017 Jun;
(123).
PMID: 28570546
Cardiomyocytes can now be derived with high efficiency from both human embryonic and human induced-Pluripotent Stem Cells (hPSC). hPSC-derived cardiomyocytes (hPSC-CMs) are increasingly recognized as having great value for modeling...
6.
Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, et al.
Eur Heart J
. 2017 Feb;
38(4):292-301.
PMID: 28182242
No abstract available.
7.
Sala L, Yu Z, Ward-van Oostwaard D, van Veldhoven J, Moretti A, Laugwitz K, et al.
EMBO Mol Med
. 2016 Jul;
8(9):1065-81.
PMID: 27470144
Long-QT syndrome (LQTS) is an arrhythmogenic disorder characterised by prolongation of the QT interval in the electrocardiogram, which can lead to sudden cardiac death. Pharmacological treatments are far from optimal...
8.
Kosmidis G, Bellin M, Ribeiro M, van Meer B, Ward-van Oostwaard D, Passier R, et al.
Biochem Biophys Res Commun
. 2015 Oct;
467(4):998-1005.
PMID: 26456652
One limitation in using human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) for disease modeling and cardiac safety pharmacology is their immature functional phenotype compared with adult cardiomyocytes. Here, we report...
9.
Zhang M, DAniello C, Verkerk A, Wrobel E, Frank S, Ward-van Oostwaard D, et al.
Proc Natl Acad Sci U S A
. 2014 Dec;
111(50):E5383-92.
PMID: 25453094
Jervell and Lange-Nielsen syndrome (JLNS) is one of the most severe life-threatening cardiac arrhythmias. Patients display delayed cardiac repolarization, associated high risk of sudden death due to ventricular tachycardia, and...
10.
Richter A, Valdimarsdottir L, Hrafnkelsdottir H, Runarsson J, Omarsdottir A, Ward-van Oostwaard D, et al.
Stem Cells
. 2014 Feb;
32(3):636-48.
PMID: 24549638
Bone morphogenetic proteins (BMPs) initiate differentiation in human embryonic stem cells (hESCs) but the exact mechanisms have not been fully elucidated. We demonstrate here that SLUG and MSX2, transcription factors...