Dorien Broekaert
Overview
Explore the profile of Dorien Broekaert including associated specialties, affiliations and a list of published articles.
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22
Citations
1320
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Recent Articles
1.
Doglioni G, Fernandez-Garcia J, Igelmann S, Altea-Manzano P, Blomme A, La Rovere R, et al.
Nature
. 2025 Jan;
638(8049):244-250.
PMID: 39743589
Lung metastases occur in up to 54% of patients with metastatic tumours. Contributing factors to this high frequency include the physical properties of the pulmonary system and a less oxidative...
2.
Vanthienen W, Fernandez-Garcia J, Baietti M, Claeys E, Van Leemputte F, Nguyen L, et al.
Front Oncol
. 2024 Sep;
14:1411983.
PMID: 39239276
Many cancer cells share with yeast a preference for fermentation over respiration, which is associated with overactive glucose uptake and breakdown, a phenomenon called the Warburg effect in cancer cells....
3.
Altea-Manzano P, Doglioni G, Liu Y, Cuadros A, Nolan E, Fernandez-Garcia J, et al.
Nat Cancer
. 2023 Feb;
4(3):344-364.
PMID: 36732635
Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation; however, some nutrients available at distant organs may inherently promote metastatic growth. We find that the lung and liver...
4.
Fernandez-Garcia J, Franco F, Parik S, Altea-Manzano P, Pane A, Broekaert D, et al.
Cell Rep
. 2022 Nov;
41(7):111639.
PMID: 36384124
T cells dynamically rewire their metabolism during an immune response. We applied single-cell RNA sequencing to CD8 T cells activated and differentiated in vitro in physiological medium to resolve these...
5.
Rossi M, Altea-Manzano P, Demicco M, Doglioni G, Bornes L, Fukano M, et al.
Nature
. 2022 Aug;
609(7927):E8.
PMID: 36042336
No abstract available.
6.
Rossi M, Altea-Manzano P, Demicco M, Doglioni G, Bornes L, Fukano M, et al.
Nature
. 2022 May;
605(7911):747-753.
PMID: 35585241
Cancer metastasis requires the transient activation of cellular programs enabling dissemination and seeding in distant organs. Genetic, transcriptional and translational heterogeneity contributes to this dynamic process. Metabolic heterogeneity has also...
7.
Gomes A, Ilter D, Low V, Drapela S, Schild T, Mullarky E, et al.
Nat Metab
. 2022 Apr;
4(4):435-443.
PMID: 35361954
The alteration of metabolic pathways is a critical strategy for cancer cells to attain the traits necessary for metastasis in disease progression. Here, we find that dysregulation of propionate metabolism...
8.
Geeraerts X, Fernandez-Garcia J, Hartmann F, de Goede K, Martens L, Elkrim Y, et al.
Cell Rep
. 2021 Dec;
37(13):110171.
PMID: 34965415
Macrophages are often prominently present in the tumor microenvironment, where distinct macrophage populations can differentially affect tumor progression. Although metabolism influences macrophage function, studies on the metabolic characteristics of ex ...
9.
Broadfield L, Duarte J, Schmieder R, Broekaert D, Veys K, Planque M, et al.
Cancer Res
. 2021 Mar;
81(8):1988-2001.
PMID: 33687947
Hepatic fat accumulation is associated with diabetes and hepatocellular carcinoma (HCC). Here, we characterize the metabolic response that high-fat availability elicits in livers before disease development. After a short term...
10.
Rinaldi G, Pranzini E, Van Elsen J, Broekaert D, Funk C, Planque M, et al.
Mol Cell
. 2020 Dec;
81(2):386-397.e7.
PMID: 33340488
In tumors, nutrient availability and metabolism are known to be important modulators of growth signaling. However, it remains elusive whether cancer cells that are growing out in the metastatic niche...