Dorian Pustina
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Explore the profile of Dorian Pustina including associated specialties, affiliations and a list of published articles.
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28
Citations
514
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Recent Articles
11.
Kinnunen K, Mullin A, Pustina D, Turner E, Burton J, Gordon M, et al.
Front Neurol
. 2021 Nov;
12:712565.
PMID: 34744964
Volumetric magnetic resonance imaging (vMRI) has been widely studied in Huntington's disease (HD) and is commonly used to assess treatment effects on brain atrophy in interventional trials. Global and regional...
12.
Kinnunen K, Schwarz A, Turner E, Pustina D, Gantman E, Gordon M, et al.
Front Neurol
. 2021 Oct;
12:712555.
PMID: 34621236
Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder that is caused by expansion of a CAG-repeat tract in the huntingtin gene and characterized by motor impairment, cognitive decline, and...
13.
Abeyasinghe P, Long J, Razi A, Pustina D, Paulsen J, Tabrizi S, et al.
Mov Disord
. 2021 May;
36(10):2282-2292.
PMID: 34014005
Background: Potential therapeutic targets and clinical trials for Huntington's disease have grown immensely in the last decade. However, to improve clinical trial outcomes, there is a need to better characterize...
14.
Polosecki P, Castro E, Rish I, Pustina D, Warner J, Wood A, et al.
Sci Rep
. 2020 Jan;
10(1):1252.
PMID: 31988371
Patient stratification is critical for the sensitivity of clinical trials at early stages of neurodegenerative disorders. In Huntington's disease (HD), genetic tests make cognitive, motor and brain imaging measurements possible...
15.
Baseline multimodal information predicts future motor impairment in premanifest Huntington's disease
Castro E, Polosecki P, Rish I, Pustina D, Warner J, Wood A, et al.
Neuroimage Clin
. 2018 Jul;
19:443-453.
PMID: 29984153
In Huntington's disease (HD), accurate estimates of expected future motor impairments are key for clinical trials. Individual prognosis is only partially explained by genetics. However, studies so far have focused...
16.
Pustina D, Avants B, Faseyitan O, Medaglia J, Coslett H
Neuropsychologia
. 2017 Sep;
115:154-166.
PMID: 28882479
Lesion to symptom mapping (LSM) is a crucial tool for understanding the causality of brain-behavior relationships. The analyses are typically performed by applying statistical methods on individual brain voxels (VLSM),...
17.
Mirman D, Landrigan J, Kokolis S, Verillo S, Ferrara C, Pustina D
Neuropsychologia
. 2017 Aug;
115:112-123.
PMID: 28847712
Voxel-based lesion-symptom mapping (VLSM) is an important method for basic and translational human neuroscience research. VLSM leverages modern neuroimaging analysis techniques to build on the classic approach of examining the...
18.
Pustina D, Coslett H, Ungar L, Faseyitan O, Medaglia J, Avants B, et al.
Hum Brain Mapp
. 2017 Aug;
38(11):5603-5615.
PMID: 28782862
The severity of post-stroke aphasia and the potential for recovery are highly variable and difficult to predict. Evidence suggests that optimal estimation of aphasia severity requires the integration of multiple...
19.
He X, Doucet G, Pustina D, Sperling M, Sharan A, Tracy J
Neurology
. 2017 May;
88(24):2285-2293.
PMID: 28515267
Objective: To characterize the presurgical brain functional architecture presented in patients with temporal lobe epilepsy (TLE) using graph theoretical measures of resting-state fMRI data and to test its association with...
20.
Pustina D, Coslett H, Turkeltaub P, Tustison N, Schwartz M, Avants B
Hum Brain Mapp
. 2016 Jan;
37(4):1405-21.
PMID: 26756101
The gold standard for identifying stroke lesions is manual tracing, a method that is known to be observer dependent and time consuming, thus impractical for big data studies. We propose...