Donglei Leng
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Explore the profile of Donglei Leng including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
118
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Recent Articles
1.
Zhuo X, Ochner J, Leng D, Fodera V, Lobmann K
Eur J Pharm Biopharm
. 2024 Apr;
198:114274.
PMID: 38561067
Amorphous solid dispersions (ASDs) using proteins as carriers have emerged as a promising strategy for stabilizing amorphous drug molecules. Proteins possess diverse three-dimensional structures that significantly influence their own properties...
2.
Zhuo X, Tozzetti M, Arnous A, Leng D, Fodera V, Lobmann K
Int J Pharm
. 2024 Feb;
653:123887.
PMID: 38346599
Proteins acting as carriers in amorphous solid dispersions (ASDs) demonstrate a notable sensitivity to the spray drying process, potentially leading to changes in their conformation. The main aim of this...
3.
Zhuo X, Sener Z, Kabedev A, Zhao M, Arnous A, Leng D, et al.
Mol Pharm
. 2023 Sep;
20(10):5206-5213.
PMID: 37669430
Protein-based amorphous solid dispersions (ASDs) have emerged as a promising approach for enhancing solubility in comparison to crystalline drugs. The dissolution behavior of protein-based amorphous solid dispersions (ASDs) was investigated...
4.
Leng D, Bulduk B, Widmer T, Wiborg O, Sanchez-Felix M, Lobmann K
Pharm Res
. 2023 May;
40(7):1865-1872.
PMID: 37237165
Purpose: Whey protein isolate (WPI) has previously been shown to be a promising new excipient for the development of amorphous solid dispersions (ASD) at a high drug loading of 50%...
5.
Leng D, Bulduk B, Anlahr J, Mullers W, Lobmann K
Int J Pharm
. 2023 Feb;
635:122693.
PMID: 36754186
Amorphous solid dispersions (ASD) have been considered as one of the most effective strategies to increase solubility and dissolution rate of poorly water-soluble drugs. Carriers, in which the poorly water-soluble...
6.
Zhuo X, Margrethe Brekstad Kjellin M, Schaal Z, Zhang T, Lobmann K, Leng D
Pharmaceutics
. 2023 Jan;
15(1).
PMID: 36678757
Amorphous solid dispersions (ASDs) based on proteins as co-formers have previously shown promising potential to improve the solubility and bioavailability of poorly water-soluble drugs. In particular, whey proteins have shown...
7.
Kabedev A, Zhuo X, Leng D, Fodera V, Zhao M, Larsson P, et al.
Mol Pharm
. 2022 Sep;
19(11):3922-3933.
PMID: 36135343
Proteins, and in particular whey proteins, have recently been introduced as a promising excipient class for stabilizing amorphous solid dispersions. However, despite the efficacy of the approach, the molecular mechanisms...
8.
Leng D, Kissi E, Lobmann K, Thanki K, Fattal E, Rades T, et al.
AAPS PharmSciTech
. 2019 Mar;
20(3):137.
PMID: 30847607
Corticosteroid resistance poses a major challenge to effective treatment of chronic obstructive pulmonary diseases. However, corticosteroid resistance can be overcome by co-administration of theophylline. The aim of this study was...
9.
Leng D, Thanki K, Foged C, Yang M
Pharm Res
. 2018 Nov;
35(12):247.
PMID: 30386927
Purpose: The spray drying process is widely applied for pharmaceutical particle engineering. The purpose of this study was to investigate advantages and disadvantages of two-fluid nozzle and three-fluid nozzle spray...
10.
Sun F, Ye C, Thanki K, Leng D, van Hasselt P, Hennink W, et al.
Colloids Surf B Biointerfaces
. 2018 Jul;
170:521-528.
PMID: 29966905
Poorly soluble vitamin K cannot be absorbed by patients suffering from cholestasis due to extremely low level of bile salts in the intestine. A formulation of vitamin K including glycocholic...