Donald N Cook
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Explore the profile of Donald N Cook including associated specialties, affiliations and a list of published articles.
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78
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3479
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Recent Articles
1.
Wen Z, Pramanik A, Lewicki S, Jung Y, Gao Z, Randle J, et al.
ACS Pharmacol Transl Sci
. 2024 Oct;
7(10):3255-3278.
PMID: 39421658
Tethered glycoconjugates of a naphthalene- and piperidine-containing antagonist of the P2Y receptor (PPTN) were synthesized, and their nM receptor binding affinity was determined using a fluorescent tracer in hP2YR-expressing whole...
2.
Wilkinson C, Nakano K, Grimm S, Whitehead G, Arao Y, Blackshear P, et al.
Res Sq
. 2024 Jun;
PMID: 38883724
The severity of allergic asthma is driven by the balance between allergen-specific T regulatory (Treg) and T helper (Th)2 cells. However, it is unclear whether specific subsets of conventional dendritic...
3.
Alraies Z, Rivera C, Delgado M, Sanseau D, Maurin M, Amadio R, et al.
Nat Immunol
. 2024 Jun;
25(7):1193-1206.
PMID: 38834865
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These cells can adapt to such deformation events...
4.
Nakano K, Whitehead G, Lyons-Cohen M, Grimm S, Wilkinson C, Izumi G, et al.
J Allergy Clin Immunol
. 2023 Nov;
153(2):487-502.e9.
PMID: 37956733
Background: Allergic asthma is driven largely by allergen-specific T2 cells, which develop in regional lymph nodes on the interaction of naive CD4 T cells with allergen-bearing dendritic cells that migrate...
5.
Immormino R, Smeekens J, Mathai P, Clough K, Nguyen J, Ghio A, et al.
Allergy
. 2023 Oct;
79(2):432-444.
PMID: 37804001
Background: Environmental exposure to peanut through non-oral routes is a risk factor for peanut allergy. Early-life exposure to air pollutants, including particulate matter (PM), is associated with sensitization to foods...
6.
Li W, Nakano H, Fan W, Li Y, Sil P, Nakano K, et al.
JCI Insight
. 2023 Aug;
8(17).
PMID: 37581941
DNASE1L3, an enzyme highly expressed in DCs, is functionally important for regulating autoimmune responses to self-DNA and chromatin. Deficiency of DNASE1L3 leads to development of autoimmune diseases in both humans...
7.
Lee E, Choi W, Burkholder A, Perera L, Mack J, Miller F, et al.
Front Genet
. 2023 Jul;
14:1173676.
PMID: 37415598
Asthma is a chronic disease of the airways that impairs normal breathing. The etiology of asthma is complex and involves multiple factors, including the environment and genetics, especially the distinct...
8.
Wen Z, Pramanik A, Lewicki S, Jung Y, Gao Z, Randle J, et al.
J Med Chem
. 2023 Jun;
66(13):9076-9094.
PMID: 37382926
P2Y receptor (P2YR) is activated by extracellular UDP-glucose, a damage-associated molecular pattern that promotes inflammation in the kidney, lung, fat tissue, and elsewhere. Thus, selective P2YR antagonists are potentially useful...
9.
Whitehead G, Karcz T, Tosh D, Jung Y, Wen Z, Campbell R, et al.
ACS Pharmacol Transl Sci
. 2022 Oct;
5(10):973-984.
PMID: 36268115
COVID-19 disease is associated with progressive accumulation of SARS-CoV-2-specific mRNA, which is recognized by innate immune receptors, such as TLR3. This in turn leads to dysregulated production of multiple cytokines,...
10.
Nakano H, Cook D
Am J Respir Cell Mol Biol
. 2022 Oct;
68(2):127-128.
PMID: 36264767
No abstract available.