Dominik Schelshorn
Overview
Explore the profile of Dominik Schelshorn including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
5
Citations
126
Followers
0
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Recent Articles
1.
Seven A, Barros-Alvarez X, de Lapeyriere M, Papasergi-Scott M, Robertson M, Zhang C, et al.
Nature
. 2021 Jul;
595(7867):450-454.
PMID: 34194039
Family C G-protein-coupled receptors (GPCRs) operate as obligate dimers with extracellular domains that recognize small ligands, leading to G-protein activation on the transmembrane (TM) domains of these receptors by an...
2.
Lutjens R, Perry B, Schelshorn D, Rocher J
Drug Discov Today Technol
. 2013 Sep;
10(2):e253-60.
PMID: 24050276
Allosteric modulators (AMs) are a promising avenue towards safe and selective drugs. AMs can interact selectively with unique domains distinct from the endogenous ligand binding site of receptors, up- or...
3.
Schelshorn D, Joly F, Mutel S, Hampe C, Breton B, Mutel V, et al.
Mol Pharmacol
. 2011 Nov;
81(3):309-18.
PMID: 22108912
Activation of G-protein-coupled receptors (GPCRs) results in a variety of cellular responses, such as binding to the same receptor of different ligands that activate distinct downstream cascades. Additional signaling complexity...
4.
Hinkelbein J, Feldmann Jr R, Schubert C, Peterka A, Schelshorn D, Maurer M, et al.
J Trauma
. 2009 Apr;
66(4):1065-75.
PMID: 19359916
Objectives: Despite a decreased mortality from sepsis, the absolute number of sepsis-related deaths has actually increased during the last years. At present, there are no biological markers available that can...
5.
Hinkelbein J, Feldmann Jr R, Peterka A, Schubert C, Schelshorn D, Maurer M, et al.
Curr Neurovasc Res
. 2007 Nov;
4(4):280-8.
PMID: 18045154
The cause of brain dysfunction during sepsis and septic encephalopathy is still under ongoing research. Sepsis induced changes in cerebral protein expression may play a significant role in the understanding...