Dmitry L Usanov
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Explore the profile of Dmitry L Usanov including associated specialties, affiliations and a list of published articles.
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Citations
259
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Recent Articles
1.
Peterson A, Rangwala A, Thakur M, Ward P, Hung C, Outhwaite I, et al.
Nat Chem Biol
. 2022 Sep;
18(11):1184-1195.
PMID: 36163383
Although cyclophilins are attractive targets for probing biology and therapeutic intervention, no subtype-selective cyclophilin inhibitors have been described. We discovered novel cyclophilin inhibitors from the in vitro selection of a...
2.
Reidenbach A, Mesleh M, Casalena D, Vallabh S, Dahlin J, Leed A, et al.
J Biol Chem
. 2020 Jul;
295(39):13516-13531.
PMID: 32723867
Prion disease is a rapidly progressive neurodegenerative disorder caused by misfolding and aggregation of the prion protein (PrP), and there are currently no therapeutic options. PrP ligands could theoretically antagonize...
3.
Afanasyev O, Kuchuk E, Usanov D, Chusov D
Chem Rev
. 2019 Oct;
119(23):11857-11911.
PMID: 31633341
Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and the ubiquitous presence of amines among biologically active compounds. It is one of...
4.
Usanov D, Chan A, Maianti J, Liu D
Nat Chem
. 2019 Oct;
11(11):1067.
PMID: 31576016
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
5.
Runikhina S, Usanov D, Chizhov A, Chusov D
Org Lett
. 2018 Dec;
20(24):7856-7859.
PMID: 30525672
We developed a ruthenium-catalyzed reductive ester synthesis from aldehydes or ketones and carboxylic acids using carbon monoxide as a deoxygenative agent. Multiple factors influencing the outcome of the reaction were...
6.
Usanov D, Chan A, Maianti J, Liu D
Nat Chem
. 2018 Apr;
10(7):704-714.
PMID: 29610462
DNA-encoded libraries have emerged as a widely used resource for the discovery of bioactive small molecules, and offer substantial advantages compared with conventional small-molecule libraries. Here, we have developed and...
7.
Afanasyev O, Usanov D, Chusov D
Org Biomol Chem
. 2017 Nov;
15(48):10164-10166.
PMID: 29184946
We developed solvent-free reductive amination without an external hydrogen source using iron pentacarbonyl as a reducing agent. Neither a catalyst nor any other additives were employed. Various types of substrates...
8.
Kolesnikov P, Usanov D, Muratov K, Chusov D
Org Lett
. 2017 Sep;
19(20):5657-5660.
PMID: 28961011
Rh-catalyzed one-step reductive amidation of aldehydes has been developed. The protocol does not require an external hydrogen source and employs carbon monoxide as a deoxygenative agent. The direction of the...
9.
Moskovets A, Usanov D, Afanasyev O, Fastovskiy V, Molotkov A, Muratov K, et al.
Org Biomol Chem
. 2017 Jul;
15(30):6384-6387.
PMID: 28726957
Development of novel, sustainable catalytic methodologies to provide access to amines represents a goal of fundamental importance. Herein we describe a systematic study for the construction of a variety of...
10.
Afanasyev O, Tsygankov A, Usanov D, Chusov D
Org Lett
. 2016 Nov;
18(22):5968-5970.
PMID: 27802047
An interesting catalytic dichotomy was discovered: switching between simple ligand-free catalysts leads to fundamentally different outcomes of reductive reaction between amines and α-carbonylcyclopropanes. Whereas a rhodium catalyst leads to the...