Dmitri Simberg
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Explore the profile of Dmitri Simberg including associated specialties, affiliations and a list of published articles.
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83
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1790
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Recent Articles
1.
Escobedo H, Zawadzki N, Till J, Vazquez-Torres A, Wang G, Simberg D, et al.
Nanomedicine
. 2025 Mar;
65:102812.
PMID: 40024488
Among hospital-acquired infections, Pseudomonas aeruginosa-associated urinary tract infections (UTIs) are mainly caused by indwelling urethral catheters (catheter-associated UTIs or CAUTIs) and are difficult to treat, resulting in high rates of...
2.
Li Y, Saba L, Scheinman R, Banda N, Holers M, Monte A, et al.
ACS Nano
. 2024 Oct;
18(42):28649-28658.
PMID: 39395006
Systemic administration of nanomedicines results in the activation of the complement cascade, promoting phagocytic uptake and triggering proinflammatory responses. Identifying the biomarkers that can predict the "risk" of abnormally high...
3.
Anchordoquy T, Artzi N, Balyasnikova I, Barenholz Y, La-Beck N, Brenner J, et al.
ACS Nano
. 2024 May;
18(22):13983-13999.
PMID: 38767983
In recent years, steady progress has been made in synthesizing and characterizing engineered nanoparticles, resulting in several approved drugs and multiple promising candidates in clinical trials. Regulatory agencies such as...
4.
Li Y, Ettah U, Jacques S, Gaikwad H, Monte A, Dylla L, et al.
Mol Pharm
. 2024 May;
21(6):3053-3060.
PMID: 38743264
There is considerable interest in quantifying anti-PEG antibodies, given their potential involvement in accelerated clearance, complement activation, neutralization, and acute reactions associated with drug delivery systems. Published and commercially available...
5.
Holers V, Frank R, Zuscik M, Keeter C, Scheinman R, Striebich C, et al.
Immune Netw
. 2024 May;
24(2):e17.
PMID: 38725672
We have reported that anterior cruciate ligament (ACL) injury leads to the differential dysregulation of the complement system in the synovium as compared to meniscus tear (MT) and proposed this...
6.
Li Y, Monte A, Dylla L, Moghimi S, Simberg D
J Immunol Methods
. 2024 Apr;
528:113668.
PMID: 38574804
Complement plays a critical role in the immune response toward nanomaterials. The complement attack on a foreign surface results in the deposition of C3, assembly of C3 convertases, the release...
7.
Li Y, Moein Moghimi S, Simberg D
Curr Opin Biotechnol
. 2023 Dec;
85:103044.
PMID: 38091875
Immune recognition and uptake of nanoparticles remain the hot topic in nanomedicine research. Complement is the central player in the immune recognition of engineered nanoparticles. Here, we summarize the accumulated...
8.
Haroon H, Dhillon E, Farhangrazi Z, Trohopoulos P, Simberg D, Moghimi S
Eur J Pharm Biopharm
. 2023 Nov;
193:227-240.
PMID: 37949325
The complement system is a multicomponent and multifunctional arm of the innate immune system. Complement contributes to non-specific host defence and maintains homeostasis through multifaceted processes and pathways, including crosstalk...
9.
Li Y, Jacques S, Gaikwad H, Wang G, Banda N, Holers V, et al.
Nat Nanotechnol
. 2023 Oct;
19(2):246-254.
PMID: 37798566
Effective inhibition of the complement system is needed to prevent the accelerated clearance of nanomaterials by complement cascade and inflammatory responses. Here we show that a fusion construct consisting of...
10.
Moghimi S, Haroon H, Yaghmur A, Hunter A, Papini E, Farhangrazi Z, et al.
J Control Release
. 2023 Feb;
356:115-129.
PMID: 36841287
The complement system, professional phagocytes and other cells such as Natural killer cells and mast cells are among the important components of the innate arm of the immune system. These...