Dirk Grundemann
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Explore the profile of Dirk Grundemann including associated specialties, affiliations and a list of published articles.
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52
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786
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Recent Articles
1.
Flogel S, Tust M, Boussettaoui S, Fischer D, Grundemann D
FEBS Open Bio
. 2025 Mar;
PMID: 40052353
The functional characterization of plasma membrane transport proteins often relies on their heterologous expression in cultured cells. However, some transporters exhibit low activity, hindering meaningful functional assays. Heterologous expression is...
2.
Dong Q, Chen Z, Boland J, Dokos C, Hagos Y, Kuhne A, et al.
Clin Transl Sci
. 2025 Feb;
18(2):e70141.
PMID: 39895366
Clearance of an intravenous iohexol dose of 3235 mg is used to assess glomerular filtration rate (GFR), although systematic assessment of its pharmacokinetic (PK) properties is incomplete. The objectives of...
3.
Flogel S, Strater M, Fischer D, Grundemann D
FEBS J
. 2025 Jan;
292(5):1124-1140.
PMID: 39792585
Creatine is essential for ATP regeneration in energy-demanding cells. Creatine deficiency results in severe neurodevelopmental impairments. In the brain, creatine is synthesized locally by oligodendrocytes to supply neighboring neurons. Neuronal...
4.
Gobrecht P, Gebel J, Leibinger M, Zeitler C, Chen Z, Grundemann D, et al.
Phytomedicine
. 2024 May;
129:155641.
PMID: 38718639
Background: The limited regenerative capacity of injured axons hinders functional recovery after nerve injury. Although no drugs are currently available in the clinic to accelerate axon regeneration, recent studies show...
5.
Tust M, Muller J, Fischer D, Grundemann D
Int J Mol Sci
. 2023 Oct;
24(20).
PMID: 37894870
Chronic kidney disease (CKD) is a global health concern affecting millions worldwide. One of the critical challenges in CKD is the accumulation of uremic toxins such as p-cresol sulfate (pCS)...
6.
Hsin C, Kuehne A, Gu Y, Jedlitschky G, Hagos Y, Grundemann D, et al.
Eur J Pharm Sci
. 2023 May;
186:106459.
PMID: 37142000
Purpose: Cocktails of transporter probe drugs are used in vivo to assess transporter activity and respective drug-drug interactions. An inhibitory effect of components on transporter activities should be ruled out....
7.
Hartmann L, Seebeck F, Schmalz H, Grundemann D
Free Radic Biol Med
. 2023 Feb;
198:12-26.
PMID: 36736443
Recently we have uncovered a non-enzymatic multi-step cycle for the regeneration of ergothioneine (ET), after reaction with noxious singlet oxygen (O), by glutathione (GSH). When living cells were loaded with...
8.
Schmitz K, Turnwald E, Kretschmer T, Janoschek R, Bae-Gartz I, Vossbrecher K, et al.
Nutrients
. 2022 Jun;
14(11).
PMID: 35684088
With the gaining prevalence of obesity, related risks during pregnancy are rising. Inflammation and oxidative stress are considered key mechanisms arising in white adipose tissue (WAT) sparking obesity-associated complications and...
9.
Muller J, Grundemann D
Int J Mol Sci
. 2022 May;
23(9).
PMID: 35563081
The ergothioneine transporter ETT (formerly OCTN1; human gene symbol ) is a powerful and highly specific transporter for the uptake of ergothioneine (ET). Recently, Sparreboom et al. reported that the...
10.
Grievink H, Shamni O, Krajewski S, Steczek L, Grundemann D, Mishani E, et al.
Mol Imaging Biol
. 2022 Apr;
24(5):1-9.
PMID: 35441946
Purpose: Quaternary ammonium salts have demonstrated marked accumulation in the left ventricular (LV) myocardium of rodents and swine. To investigate the mechanism underlying this uptake, the present study examined the...