Dirk E Smith
Overview
Explore the profile of Dirk E Smith including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
2911
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Recent Articles
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Tyler M, Russell C, Smith D, Rottman J, Padro Dietz C, Hu X, et al.
J Allergy Clin Immunol
. 2016 Nov;
139(3):1061-1064.e4.
PMID: 27871878
No abstract available.
3.
Vannella K, Ramalingam T, Borthwick L, Barron L, Hart K, Thompson R, et al.
Sci Transl Med
. 2016 May;
8(337):337ra65.
PMID: 27147589
Thymic stromal lymphopoietin (TSLP), interleukin-25 (IL-25), and IL-33 are important initiators of type 2-associated mucosal inflammation and immunity. However, their role in the maintenance of progressive type 2 inflammation and...
4.
De Salvo C, Wang X, Pastorelli L, Mattioli B, Omenetti S, Buela K, et al.
Am J Pathol
. 2016 Feb;
186(4):885-98.
PMID: 26908008
Although a clear association has been established between IL-33 and inflammatory bowel disease, mechanistic studies to date, primarily using acute murine models of colitis, have yielded contradicting results, demonstrating both...
5.
Martin P, Palmer G, Rodriguez E, Woldt E, Mean I, James R, et al.
Immun Inflamm Dis
. 2015 Sep;
3(3):239-46.
PMID: 26417439
Interleukin (IL)-33 is a cytokine of the IL-1 family, which signals through the ST2 receptor. Previous work demonstrated that the systemic administration of recombinant IL-33 reduces the development of atherosclerosis...
6.
Lai Y, Altemeier W, Vandree J, Piliponsky A, Johnson B, Appel C, et al.
J Allergy Clin Immunol
. 2013 Nov;
133(5):1448-55.
PMID: 24220317
Background: Exercise-induced bronchoconstriction (EIB) is a prototypical feature of indirect airway hyperresponsiveness. Mast cells are implicated in EIB, but the characteristics, regulation, and function of mast cells in patients with...
7.
Martin P, Talabot-Ayer D, Seemayer C, Vigne S, Lamacchia C, Rodriguez E, et al.
Arthritis Res Ther
. 2013 Jan;
15(1):R13.
PMID: 23324173
Introduction: Interleukin (IL)-33 is a cytokine of the IL-1 family, which signals through the ST2 receptor. Previous work suggested implication of the IL-33/ST2 axis in the pathogenesis of human and...
8.
Hung L, Lewkowich I, Dawson L, Downey J, Yang Y, Smith D, et al.
Proc Natl Acad Sci U S A
. 2012 Dec;
110(1):282-7.
PMID: 23248269
Parasitic helminths are a major cause of chronic human disease, affecting more than 3 billion people worldwide. Host protection against most parasitic helminths relies upon Type 2 cytokine production, but...
9.
Ngoi S, St Rose M, Menoret A, Smith D, Tovey M, Adler A, et al.
Proc Natl Acad Sci U S A
. 2012 Jun;
109(26):10486-91.
PMID: 22689946
The synthetic double-stranded RNA poly(I:C) is commonly used as an adjuvant to boost CD8 T-cell function; however, polyinosinic:polycytidylic acid [poly(I:C)] can also suppress autoimmune disease. The mechanism by which a...
10.
Beamer C, Girtsman T, Seaver B, Finsaas K, Migliaccio C, Perry V, et al.
Nanotoxicology
. 2012 Jun;
7(6):1070-81.
PMID: 22686327
Allergic asthma is a chronic inflammatory disorder of the airway associated with bronchial obstruction, airway hyper-reactivity (AHR), and mucus production. The epithelium may direct and propagate asthmatic-like responses. Central to...