Dinesh Raghu
Overview
Explore the profile of Dinesh Raghu including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
260
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Recent Articles
1.
Tran K, Kumari A, Raghu D, Cox D, Goh S, Perini M, et al.
iScience
. 2024 Sep;
27(9):110754.
PMID: 39280606
The presence of precursor to exhausted (T) CD8 T cells is important to maintain robust immunity following treatment with immune checkpoint inhibition (ICI). Impressive responses to ICI are emerging in...
2.
Yakou M, Ghilas S, Tran K, Liao Y, Afshar-Sterle S, Kumari A, et al.
Sci Immunol
. 2023 Oct;
8(88):eadf2163.
PMID: 37801516
Intraepithelial lymphocytes (IELs), including αβ and γδ T cells (T-IELs), constantly survey and play a critical role in maintaining the gastrointestinal epithelium. We show that cytotoxic molecules important for defense...
3.
Liao Y, Raghu D, Pal B, Mielke L, Shi W
Bioinformatics
. 2023 Jul;
39(7).
PMID: 37462540
Summary: The 10x Genomics Chromium single-cell RNA sequencing technology is a powerful gene expression profiling platform, which is capable of profiling expression of thousands of genes in tens of thousands...
4.
Ghilas S, OKeefe R, Mielke L, Raghu D, Buchert M, Ernst M
Front Immunol
. 2022 Oct;
13:944982.
PMID: 36189323
The gut epithelium not only provides a physical barrier to separate a noxious outside from a sterile inside but also allows for highly regulated interactions between bacteria and their products,...
5.
Mejia-Hernandez J, Raghu D, Caramia F, Clemons N, Fujihara K, Riseborough T, et al.
Cancers (Basel)
. 2022 Aug;
14(16).
PMID: 36010941
Metastatic prostate cancer is a lethal disease in patients incapable of responding to therapeutic interventions. Invasive prostate cancer spread is caused by failure of the normal anti-cancer defense systems that...
6.
Raghu D, Xue H, Mielke L
Trends Immunol
. 2019 Nov;
40(12):1149-1162.
PMID: 31734149
T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages...
7.
Mielke L, Liao Y, Clemens E, Firth M, Duckworth B, Huang Q, et al.
J Exp Med
. 2019 May;
216(7):1682-1699.
PMID: 31142588
Interleukin (IL)-17-producing CD8 T (Tc17) cells have emerged as key players in host-microbiota interactions, infection, and cancer. The factors that drive their development, in contrast to interferon (IFN)-γ-producing effector CD8...
8.
Gulati T, Huang C, Caramia F, Raghu D, Paul P, Goode R, et al.
Mol Cell Proteomics
. 2018 Feb;
17(6):1170-1183.
PMID: 29463595
Prostate cancer is a common cause of cancer-related death in men. E6AP (E6-Associated Protein), an E3 ubiquitin ligase and a transcription cofactor, is elevated in a subset of prostate cancer...
9.
Raghu D, Paul P, Gulati T, Deb S, Khoo C, Russo A, et al.
Oncotarget
. 2017 May;
8(26):42939-42948.
PMID: 28477016
Prostate cancer (PC) is the most common cancer in men. Elevated levels of E3 ligase, E6-Associated Protein (E6AP) were previously linked to PC, consistent with increased protein expression in a...
10.
Miranda P, Buckley D, Raghu D, Pang J, Takano E, Vijayakumaran R, et al.
J Pathol
. 2017 Jan;
241(5):661-670.
PMID: 28097652
Mutation of the key tumour suppressor p53 defines a transition in the progression towards aggressive and metastatic breast cancer (BC) with the poorest outcome. Specifically, the p53 mutation frequency exceeds...