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Dimitri Pchejetski

Explore the profile of Dimitri Pchejetski including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 500
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Recent Articles
1.
Malavaud B, Pchejetski D, Mazerolles C, de Paiva G, Calvet C, Doumerc N, et al.
Eur J Cancer . 2010 Oct; 46(18):3417-24. PMID: 20970322
Purpose: Sphingosine kinase-1 (SphK1) was shown in preclinical models and non-genitourinary cancers to be instrumental in cancer progression, adaptation to hypoxia and in tumour angiogenesis. No data were available in...
2.
Guillermet-Guibert J, Davenne L, Pchejetski D, Saint-Laurent N, Brizuela L, Guilbeau-Frugier C, et al.
Mol Cancer Ther . 2009 Apr; 8(4):809-20. PMID: 19372554
Defeating pancreatic cancer resistance to the chemotherapeutic drug gemcitabine remains a challenge to treat this deadly cancer. Targeting the sphingolipid metabolism for improving tumor chemosensitivity has recently emerged as a...
3.
Pchejetski D, Doumerc N, Golzio M, Naymark M, Teissie J, Kohama T, et al.
Mol Cancer Ther . 2008 Jul; 7(7):1836-45. PMID: 18644996
We have previously reported that, in prostate cancer, inhibition of the oncogenic sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) pathway is a key element in chemotherapy-induced apoptosis. Here, we show that selective pharmacologic...
4.
Gomez-Brouchet A, Pchejetski D, Brizuela L, Garcia V, Altie M, Maddelein M, et al.
Mol Pharmacol . 2007 May; 72(2):341-9. PMID: 17522181
We examined the role of sphingosine kinase-1 (SphK1), a critical regulator of the ceramide/sphingosine 1-phosphate (S1P) biostat, in the regulation of death and survival of SH-SY5Y neuroblastoma cells in response...
5.
Pchejetski D, Kunduzova O, Dayon A, Calise D, Seguelas M, Leducq N, et al.
Circ Res . 2006 Dec; 100(1):41-9. PMID: 17158340
The mitochondrial enzyme monoamine oxidase (MAO), its isoform MAO-A, plays a major role in reactive oxygen species-dependent cardiomyocyte apoptosis and postischemic cardiac damage. In the current study, we investigated whether...
6.
Pchejetski D, Golzio M, Bonhoure E, Calvet C, Doumerc N, Garcia V, et al.
Cancer Res . 2005 Dec; 65(24):11667-75. PMID: 16357178
Systemic chemotherapy was considered of modest efficacy in prostate cancer until the recent introduction of taxanes. We took advantage of the known differential effect of camptothecin and docetaxel on human...
7.
Akimova O, Pchejetski D, Hamet P, Orlov S
Pflugers Arch . 2005 Jul; 451(4):569-78. PMID: 16052351
The signaling cascade resulting in the death of several types of cells treated with ouabain or other cardiotonic steroids (CTS) remains poorly understood. Recently, we observed that ouabain kills epithelial...
8.
Le Scolan E, Pchejetski D, Banno Y, Denis N, Mayeux P, Vainchenker W, et al.
Blood . 2005 May; 106(5):1808-16. PMID: 15890687
The erythroleukemia developed by spi-1/PU.1-transgenic mice is a model of multistage oncogenic process. Isolation of tumor cells representing discrete stages of leukemic progression enables the dissection of some of the...
9.
Orlov S, Thorin-Trescases N, Pchejetski D, Taurin S, Farhat N, Tremblay J, et al.
Pflugers Arch . 2004 Apr; 448(3):335-45. PMID: 15069561
Recent studies have demonstrated the tissue-specific effect of Na+/K+ pump inhibition by ouabain and other cardiac glycosides on cell viability. The vascular endothelium is an initial target of cardiac glycosides...
10.
Brindikova T, Bourcier N, Torres B, Pchejetski D, Gekle M, Maximov G, et al.
Am J Physiol Cell Physiol . 2003 Aug; 285(6):C1445-53. PMID: 12917108
Purinergic inhibition of Na-K-Cl cotransport has been noted in various renal epithelial cells derived from the collecting tubule, including Madin-Darby canine kidney (MDCK) cells. In recent studies, we have observed...