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Digna Velez Edwards

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Recent Articles
1.
Fejzo M, Wang X, Zollner J, Pujol Gualdo N, Pujol-Gualdo N, Laisk T, et al.
Res Sq . 2025 Jan; PMID: 39764105
While most pregnancies are affected by nausea and vomiting, hyperemesis gravidarum (HG) is at the severe end of the clinical spectrum and is associated with dehydration, undernutrition, and adverse maternal,...
2.
Jasper E, Hellwege J, Greene C, Edwards T, Edwards D
Res Sq . 2024 Jun; PMID: 38854080
Increasing gestational weight gain (GWG) is linked to adverse outcomes in pregnant persons and their children. The Early Growth Genetics (EGG) Consortium identified previously genetic variants that could contribute to...
3.
Dareng E, Coetzee S, Tyrer J, Peng P, Rosenow W, Chen S, et al.
Am J Hum Genet . 2024 May; 111(6):1061-1083. PMID: 38723632
To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981...
4.
Griffin E, Hooker G, Grace M, Kaphingst K, Edwards D, Zhao Z, et al.
J Genet Couns . 2023 Mar; 32(4):812-822. PMID: 36872475
Non-invasive prenatal screening (NIPS) using cell-free DNA is a screening test for fetal aneuploidy offered by a variety of prenatal healthcare providers. Guidelines for genetic screening consistently recommend that providers...
5.
DeVries A, Dennis J, Tyrer J, Peng P, Coetzee S, Reyes A, et al.
J Natl Cancer Inst . 2022 Oct; 114(11):1533-1544. PMID: 36210504
Background: Known risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles...
6.
Dareng E, Tyrer J, Barnes D, Jones M, Yang X, Aben K, et al.
Eur J Hum Genet . 2022 Mar; 30(5):630-631. PMID: 35314806
No abstract available.
7.
Dareng E, Tyrer J, Barnes D, Jones M, Yang X, Aben K, et al.
Eur J Hum Genet . 2022 Jan; 30(3):349-362. PMID: 35027648
Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance...
8.
Martucci V, Richmond B, Davis L, Blackwell T, Cox N, Samuels D, et al.
Hum Mol Genet . 2021 Mar; 30(7):619-628. PMID: 33704461
Major depressive disorder (MDD) is a common comorbidity in chronic obstructive pulmonary disease (COPD), affecting up to 57% of patients with COPD. Although the comorbidity of COPD and MDD is...
9.
Glubb D, Thompson D, Aben K, Alsulimani A, Amant F, Annibali D, et al.
Cancer Epidemiol Biomarkers Prev . 2020 Nov; 30(1):217-228. PMID: 33144283
Background: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions,...
10.
Gao C, Osmundson S, Yan X, Edwards D, Malin B, Chen Y
Stud Health Technol Inform . 2019 Aug; 264:148-152. PMID: 31437903
Severe maternal morbidity (SMM) encompasses a wide range of serious health complications that would likely result in death without in-time medical attention. It has been recognized that various demographic factors...