Diego Nunez-Villanueva
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Explore the profile of Diego Nunez-Villanueva including associated specialties, affiliations and a list of published articles.
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22
Citations
164
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Recent Articles
1.
Bolgar P, Dhiman M, Nunez-Villanueva D, Hunter C
Chem Rev
. 2025 Jan;
125(3):1629-1657.
PMID: 39804998
Template-directed synthesis has become a powerful methodology to access complex molecules. Noncovalent templating has been widely used in the last few decades, but less attention has been paid to covalent...
2.
Nunez-Villanueva D, Hunter C
Org Chem Front
. 2023 Nov;
10(23):5950-5957.
PMID: 38022796
The development of methods for replication of synthetic information oligomers will underpin the use of directed evolution to search new chemical space. Template-directed replication of triazole oligomers has been achieved...
3.
Nunez-Villanueva D, Plata-Ruiz A, Romero-Muniz I, Martin-Perez I, Infantes L, Gonzalez-Muniz R, et al.
J Org Chem
. 2023 Sep;
88(20):14688-14696.
PMID: 37774108
β-Turns are one of the most common secondary structures found in proteins. In the interest of developing novel β-turn inducers, a diastereopure azepane-derived quaternary amino acid has been incorporated into...
4.
Nunez-Villanueva D, Hunter C
Org Biomol Chem
. 2022 Oct;
20(42):8285-8292.
PMID: 36226964
Covalent template-directed synthesis can be used to replicate synthetic oligomers, but success depends critically on the conformational properties of the backbone. Here we investigate how the choice of monomer building...
5.
Nunez-Villanueva D, Hunter C
Chem Commun (Camb)
. 2022 Sep;
58(78):11005-11008.
PMID: 36094173
Salt bridges were used to attach polymerisable amidine monomers to an oligomeric benzoic acid template. CuAAC oligomerisation reactions in the presence of a benzoic acid 3-mer template gave the amidine...
6.
Nunez-Villanueva D, Hunter C
J Am Chem Soc
. 2022 Sep;
144(37):17307-17316.
PMID: 36082527
Template-directed synthesis of nucleic acids in the polymerase chain reaction is based on the use of a primer, which is elongated in the replication process. The attachment of a high...
7.
Nunez-Villanueva D, Ciaccia M, Hunter C
RSC Adv
. 2022 May;
9(51):29566-29569.
PMID: 35531529
Covalent template-directed synthesis was used to oligomerise monomer building blocks in a controlled manner to give exclusively the linear trimer. Competing reaction pathways were blocked by addition of a large...
8.
Iadevaia G, Swain J, Nunez-Villanueva D, Bond A, Hunter C
Chem Sci
. 2021 Aug;
12(30):10218-10226.
PMID: 34377409
Oligomers equipped with complementary recognition units have the potential to encode and express chemical information in the same way as nucleic acids. The supramolecular assembly properties of -phenylene ethynylene polymers...
9.
Nunez-Villanueva D, Hunter C
Chem Sci
. 2021 Jun;
12(11):4063-4068.
PMID: 34163677
Replication of sequence information with mutation is the molecular basis for the evolution of functional biopolymers. Covalent template-directed synthesis has been used to replicate sequence information in synthetic oligomers, and...
10.
Nunez-Villanueva D, Hunter C
Acc Chem Res
. 2021 Feb;
54(5):1298-1306.
PMID: 33554599
The holy grail identified by Orgel in his 1995 Account was the development of novel chemical systems that evolve using reactions in which replication and information transfer occur together. There...